ASSAY FOR DRUG DISCOVERY BASED ON IN VITRO DIFFERENTIATED CELLS

Title:

ASSAY FOR DRUG DISCOVERY BASED ON IN VITRO DIFFERENTIATED CELLS

Document Type and Number:

WIPO Patent Application WO/2005/108598

Kind Code:

A1

Abstract:

Provided are assay systems for determining the therapeutic or toxic effect of a putative drug based on assaying its activity in cells which have been differentiated in vitro from stem cells, and induced to display a phenotype that resembles a disease to be treated.

Inventors:

BOHLEN HERIBERT (DE)
JOENSSON KRISTINA (DE)
EHLICH ANDREAS (DE)
SCHWENGBERG SILKE (DE)

Application Number:

PCT/EP2005/005087

Publication Date:

November 17, 2005

Filing Date:

May 11, 2005

Export Citation:

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Assignee:

AXIOGENESIS AG (DE)
BOHLEN HERIBERT (DE)
JOENSSON KRISTINA (DE)
EHLICH ANDREAS (DE)
SCHWENGBERG SILKE (DE)

International Classes:

C12N5/077; C12Q1/02; G01N33/50; (IPC1-7): C12Q1/02; C12N5/06

Domestic Patent References:

WO2003006950A2	2003-01-23
WO2003080816A2	2003-10-02
WO2002051987A1	2002-07-04
WO2002074925A2	2002-09-26

Foreign References:

US6657104B1	2003-12-02
US20020160511A1	2002-10-31

Other References:

HESCHELER J ET AL: "Embryonic stem cells: A model to study structural and functional properties in cardiomyogenesis", CARDIOVASCULAR RESEARCH, XX, XX, vol. 36, no. 2, November 1997 (1997-11-01), pages 149 - 162, XP002197257, ISSN: 0008-6363

Attorney, Agent or Firm:

Steinecke, Peter (P.O Box 31 01 40, Munich, DE)

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