Title:
ASSAY FOR INHIBITORS OF EQUILIBRATIVE OR CONCENTRATIVE NUCLEOSIDE TRANSPORTERS
Document Type and Number:
WIPO Patent Application WO/2014/110097
Kind Code:
A3
Abstract:
Methods and systems for identifying inhibitors of Equilibrative Nucleoside Transporters are provided. Methods and systems for identifying inhibitors of Concentrative Nucleoside Transporters are also provided.
Inventors:
AKABAS MYLES (US)
FRAME ITHIEL JAMES (US)
DENISKIN ROMAN (US)
FRAME ITHIEL JAMES (US)
DENISKIN ROMAN (US)
Application Number:
PCT/US2014/010626
Publication Date:
October 23, 2014
Filing Date:
January 08, 2014
Export Citation:
Assignee:
EINSTEIN COLL MED (US)
International Classes:
C12P19/34; C12N1/00
Other References:
VICKERS, MF ET AL.: "Functional Production And Reconstitution Of The Human Equilibrative Nucleoside Transporter (hENT1) In Saccharomyces Cerevisiae. Interaction Of Inhibitors Of Nucleoside Transport With Recombinant hENT1 And A Glycosylation-Defective Derivative (hENT1/N48Q).", BIOCHEM. J., vol. 339, 1 April 1999 (1999-04-01), pages 21 - 32
HUTCHINS, GG ET AL.: "Gene Knockout/ Gene Therapy in Yeast Using Homologous Recombination.", ASSOCIATION FOR BIOLOGY LABORATORY EDUCATION (ABLE) 2008 PROCEEDINGS., vol. 30, 2008, pages 49 - 62
HUTCHINS, GG ET AL.: "Gene Knockout/ Gene Therapy in Yeast Using Homologous Recombination.", ASSOCIATION FOR BIOLOGY LABORATORY EDUCATION (ABLE) 2008 PROCEEDINGS., vol. 30, 2008, pages 49 - 62
Attorney, Agent or Firm:
ARNOLD, Craig, J. et al. (Rothstein & Ebeenstein LLP90 Park Avenu, New York NY, US)
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