Title:
ASSAY METHOD FOR ANTI-DRUG ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2017/188312
Kind Code:
A1
Abstract:
Provided is a method for more simply and accurately measuring ADAs that develop in a patient receiving drug-based, molecular-targeted therapy, or the like. This assay method for ADAs in an assay sample includes the following steps (1) to (4). (1) A step for preparing a specimen which includes an assay sample of ADAs; (2) a step for bringing the specimen prepared in step (1) into contact with a support on which complement C1q, an anti-C3d antibody, or an anti-C1q antibody has been immobilized; (3) a step for bringing a labeled or unlabeled antibody to the aforementioned drug into contact with the solid-phase support produced in step (2); and (4) a step for measuring the quantity of drug-ADA immune complexes bound to complement C1q, the anti-C3d antibody, or the anti-C1q antibody.
Inventors:
KASHIWAGI NOBUHITO (JP)
SAITOH FUMIO (JP)
KANEDA KENTA (JP)
MAEGAWA HIDETAKA (JP)
YAGIHASHI YUKO (JP)
SAITOH FUMIO (JP)
KANEDA KENTA (JP)
MAEGAWA HIDETAKA (JP)
YAGIHASHI YUKO (JP)
Application Number:
PCT/JP2017/016531
Publication Date:
November 02, 2017
Filing Date:
April 26, 2017
Export Citation:
Assignee:
JIMRO CO LTD (JP)
International Classes:
G01N33/53; A61P1/04; G01N33/543; A61K39/395; A61P19/02; A61P29/00
Foreign References:
| JP2012510618A | 2012-05-10 | |||
| JPH01224666A | 1989-09-07 |
Other References:
VULTAGGIO, ALESSANDRA ET AL.: "Anti-infliximab IgE and non-IgE antibodies and induction of infusion-related severe anaphylactic reactions", ALLERGY, vol. 65, no. 5, 2010, pages 657 - 661, XP055436509
KAZUO WATANABE ET AL.: "Detection of immune complexes by monoclonal anti-Clq and anti-C3d ELISA systems", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 12, no. 4, 1989, pages 369 - 378, XP055415359
KOPYLOV, URI ET AL.: "Clinical utility of antihuman lambda chain-based enzyme-linked immunosorbent assay (ELISA) versus double antigen ELISA for the detection of anti- infliximab antibodies", INFLAMMATORY BOWEL DISEASES, vol. 18, no. 9, 2012, pages 1628 - 1633
YOSHINOYA, SADAYOSHI ET AL.: "Circulating immune complex levels measured by new ELISA kits utilizing monoclonal anti-Clq and anti-C3d antibodies correlate with clinical activities of SLE but not with those of RA", JOURNAL OF CLINICAL AND LABORATORY IMMUNOLOGY, vol. 38, no. 4, 1992, pages 161 - 173
KAZUO WATANABE ET AL.: "Detection of immune complexes by monoclonal anti-Clq and anti-C3d ELISA systems", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 12, no. 4, 1989, pages 369 - 378, XP055415359
KOPYLOV, URI ET AL.: "Clinical utility of antihuman lambda chain-based enzyme-linked immunosorbent assay (ELISA) versus double antigen ELISA for the detection of anti- infliximab antibodies", INFLAMMATORY BOWEL DISEASES, vol. 18, no. 9, 2012, pages 1628 - 1633
YOSHINOYA, SADAYOSHI ET AL.: "Circulating immune complex levels measured by new ELISA kits utilizing monoclonal anti-Clq and anti-C3d antibodies correlate with clinical activities of SLE but not with those of RA", JOURNAL OF CLINICAL AND LABORATORY IMMUNOLOGY, vol. 38, no. 4, 1992, pages 161 - 173
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Download PDF:
Previous Patent: ORALLY DISINTEGRATING TABLET EVALUATING METHOD, AND ORALLY DISINTEGRATING TABLET EVALUATING DEVICE
Next Patent: RICE TRANSPLANTER
Next Patent: RICE TRANSPLANTER