Title:
ASSAY METHOD FOR DRUGS TO TREAT ATHEROSCLEROSIS, CANCER AND ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO2006036637
Kind Code:
A3
Abstract:
An assay t screen for potentially benefical drugs against atherosclerosis, cancer and Alzheimeer's disease, and their effectiveness in vitro. The assay is comprised of a system where LDL or cholesterol is given to various cells together with the drug being tested and then chromosome segregation and aneuploidy are detected using probes specific for targeted chromosomes. A related assay tests the ability of the drugs alter the fluidity of membranes.
Inventors:
POTTER HUNTINGTON (US)
Application Number:
PCT/US2005/033522
Publication Date:
June 22, 2006
Filing Date:
September 19, 2005
Export Citation:
Assignee:
UNIV SOUTH FLORIDA (US)
POTTER HUNTINGTON (US)
POTTER HUNTINGTON (US)
International Classes:
C12Q1/60
Other References:
WOOD ET AL: "Amyloid beta-proteinb interactions with members and cholesterol: causes or casualties of Alzheimer's disease", BIOCHIMICA AND BIOPHYSICA ACTA, vol. 1610, no. 2, 2003, pages 281 - 290, XP004415416
RUNZ ET AL: "Inhibition of intracellular cholesterol transport Alters Presenilin Localization nd Amyloid Precursor Protein Processing in Neuronal Cells", JOURNAL OF NEUROSCIENCE, vol. 22, no. 5, 1 March 2002 (2002-03-01), pages 1679 - 1689, XP002999959
LI ET AL: "Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation", CELL, vol. 90, 5 September 1997 (1997-09-05), pages 917 - 927, XP002999960
RUNZ ET AL: "Inhibition of intracellular cholesterol transport Alters Presenilin Localization nd Amyloid Precursor Protein Processing in Neuronal Cells", JOURNAL OF NEUROSCIENCE, vol. 22, no. 5, 1 March 2002 (2002-03-01), pages 1679 - 1689, XP002999959
LI ET AL: "Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation", CELL, vol. 90, 5 September 1997 (1997-09-05), pages 917 - 927, XP002999960
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