Title:
ASSAY SYSTEMS AND METHODS FOR DETECTING MOLECULES THAT INTERACT WITH SK2 CHANNELS
Document Type and Number:
WIPO Patent Application WO2005043973
Kind Code:
A3
Abstract:
The invention provides methods including steps of: providing cells capable of expressing SK2; contacting the cells with a test molecule; obtaining information indicative of cellular SK2 expression to obtain an SK2 Expression Value; comparing the SK2 Expression Value with a control SK2 Expression Value; and identifying a test molecule that causes the cells to display an SK2 Expression Value that is different from the control SK2 Expression Value. Also provided are methods including steps of: providing a sample comprising an SK2 channel; contacting the sample with a test molecule; obtaining information indicative of SK2 channel activity in the sample to obtain an SK2 Channel Activity Value; comparing the SK2 Channel Activity Value with a control Channel Activity Value; and identifying a test molecule that causes the SK2 Channel Activity Value to be different from the control Channel Activity Value. Methods of identifying a molecule useful for treating neuropathic pain are also described.
Inventors:
KAFTAN EDWARD (US)
DUBIN ADRIENNE (US)
CHAPLAN SANDRA R (US)
DUBIN ADRIENNE (US)
CHAPLAN SANDRA R (US)
Application Number:
PCT/US2004/035777
Publication Date:
September 22, 2005
Filing Date:
October 28, 2004
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV (BE)
KAFTAN EDWARD (US)
DUBIN ADRIENNE (US)
CHAPLAN SANDRA R (US)
KAFTAN EDWARD (US)
DUBIN ADRIENNE (US)
CHAPLAN SANDRA R (US)
International Classes:
C12Q1/00; C12Q1/68; G01N33/50; G01N33/68; (IPC1-7): C12Q1/00; C12Q1/68
Foreign References:
| US20020155531A1 | 2002-10-24 |
Download PDF: