Title:
ASSAYS AND METHODS FOR ASSESSING IMMUNOGENIC CELL DEATH, EFFICACY OF ANTI-CANCER THERAPY, AND IDENTIFYING POTENTIALLY EFFICACIOUS THERAPIES
Document Type and Number:
WIPO Patent Application WO/2015/017313
Kind Code:
A3
Abstract:
The invention provides methods, compositions and kits for identifying, assessing or quantifying immunogenic cell death, for assessing or determining the efficacy of an anti-cancer therapy, for identifying a potentially efficacious anti-cancer therapy, for identifying, assessing or quantifying the effect of an antic-cancer agent on a normal or non-cancerous cell, and for identifying a subject who may benefit from an anti-cancer therapy by detecting or measuring or quantifying one, two or three of the following: (a) cell surface translocation of calreticulin (CRT), (b) extracellular release of HMGB1, and (c) extracellular release of adenosine-5'- triphosphate (ATP). An increase in one, two or three of the above where the increase is at least about 25%, 50%), 75%, 100%), 150%), two times, three times, four times, five times or more greater than a baseline, a control or a measure made or value obtained prior to exposure to one or more anti-cancer agents may be diagnostic.
Inventors:
FORMENT SILVIA (US)
GOLDEN ENCOUSE B (US)
GOLDEN ENCOUSE B (US)
Application Number:
PCT/US2014/048385
Publication Date:
November 05, 2015
Filing Date:
July 28, 2014
Export Citation:
Assignee:
UNIV NEW YORK (US)
International Classes:
A61P35/00
Foreign References:
| US20130052160A1 | 2013-02-28 | |||
| US20120302462A1 | 2012-11-29 | |||
| US20070161001A1 | 2007-07-12 | |||
| US20070178532A1 | 2007-08-02 |
Other References:
MENGER ET AL.: "Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death", SCIENCE TRANSLATIONAL MEDICINE, vol. 4, no. 143, 18 July 2012 (2012-07-18), pages 1 - 9, XP055234012, ISSN: 1946-6234
Attorney, Agent or Firm:
SMITH, J., David (25 East Spring Valley Avenue - Suite 160Maywood, NJ, US)
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