Title:
ASSEMBLY COMPRISING AN ABSORBER OF NEAR INFRARED (NIR) LIGHT COVALENTLY LINKED TO AN INHIBITOR OF CARBONIC ANHYDRASE
Document Type and Number:
WIPO Patent Application WO/2014/136076
Kind Code:
A3
Abstract:
An assembly comprising an absorber of near infrared (NIR) light having an optical absorption cross section not lower than 100 nm2 covalently linked to an inhibitor of carbonic anhydrase (CA), process for its preparation and its use to hyperthermally target tumours or for treating other conditions in which the CA activity is involved is disclosed.
Inventors:
PINI ROBERTO (IT)
RATTO FULVIO (IT)
TATINI FRANCESCA (IT)
FUSI FRANCO (IT)
CENTI SONIA (IT)
SCOZZAFAVA ANDREA (IT)
SUPURAN CLAUDIU TRANDAFIR (IT)
CARTA FABRIZIO (IT)
CAPACCIOLI SERGIO (IT)
WITORT EWA JANINA (IT)
RATTO FULVIO (IT)
TATINI FRANCESCA (IT)
FUSI FRANCO (IT)
CENTI SONIA (IT)
SCOZZAFAVA ANDREA (IT)
SUPURAN CLAUDIU TRANDAFIR (IT)
CARTA FABRIZIO (IT)
CAPACCIOLI SERGIO (IT)
WITORT EWA JANINA (IT)
Application Number:
PCT/IB2014/059490
Publication Date:
November 20, 2014
Filing Date:
March 06, 2014
Export Citation:
Assignee:
CONSIGLIO NAZIONALE RICERCHE (IT)
International Classes:
A61K49/22; A61K41/00; A61K47/48; A61P35/00
Domestic Patent References:
| WO2012027493A1 | 2012-03-01 | |||
| WO2012154885A2 | 2012-11-15 |
Other References:
KEVIN GROVES ET AL: "Synthesis and evaluation of near-infrared fluorescent sulfonamide derivatives for imaging of hypoxia-induced carbonic anhydrase IX expression in tumors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, GB, vol. 22, no. 1, 18 October 2011 (2011-10-18), pages 653 - 657, XP028352398, ISSN: 0960-894X, [retrieved on 20111024], DOI: 10.1016/J.BMCL.2011.10.058
N. K. TAFRESHI ET AL: "Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes", CLINICAL CANCER RESEARCH, vol. 18, no. 1, 20 October 2011 (2011-10-20), pages 207 - 219, XP055086887, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-11-0238
NAYOUN WON ET AL: "Imaging depths of near-infrared quantum dots in first and second optical windows", MOLECULAR IMAGING, vol. 11, no. 4, 1 July 2012 (2012-07-01), pages 338 - 352, XP055117985, DOI: 10.2310/7290.2011.00057
MAAMAR STITI ET AL: "Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 48, 3 December 2008 (2008-12-03), pages 16130 - 16131, XP055086710, ISSN: 0002-7863, DOI: 10.1021/ja805558k
FULVIO RATTO ET AL: "Size and shape control in the overgrowth of gold nanorods", JOURNAL OF NANOPARTICLE RESEARCH ; AN INTERDISCIPLINARY FORUM FOR NANOSCALE SCIENCE AND TECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 12, no. 6, 24 July 2009 (2009-07-24), pages 2029 - 2036, XP019826965, ISSN: 1572-896X
LARS KASTRUP ET AL: "Absolute Optical Cross Section of Individual Fluorescent Molecules", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 43, no. 48, 10 December 2004 (2004-12-10), pages 6646 - 6649, XP055117906, ISSN: 1433-7851, DOI: 10.1002/anie.200461337
N. K. TAFRESHI ET AL: "Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes", CLINICAL CANCER RESEARCH, vol. 18, no. 1, 20 October 2011 (2011-10-20), pages 207 - 219, XP055086887, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-11-0238
NAYOUN WON ET AL: "Imaging depths of near-infrared quantum dots in first and second optical windows", MOLECULAR IMAGING, vol. 11, no. 4, 1 July 2012 (2012-07-01), pages 338 - 352, XP055117985, DOI: 10.2310/7290.2011.00057
MAAMAR STITI ET AL: "Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 48, 3 December 2008 (2008-12-03), pages 16130 - 16131, XP055086710, ISSN: 0002-7863, DOI: 10.1021/ja805558k
FULVIO RATTO ET AL: "Size and shape control in the overgrowth of gold nanorods", JOURNAL OF NANOPARTICLE RESEARCH ; AN INTERDISCIPLINARY FORUM FOR NANOSCALE SCIENCE AND TECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 12, no. 6, 24 July 2009 (2009-07-24), pages 2029 - 2036, XP019826965, ISSN: 1572-896X
LARS KASTRUP ET AL: "Absolute Optical Cross Section of Individual Fluorescent Molecules", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 43, no. 48, 10 December 2004 (2004-12-10), pages 6646 - 6649, XP055117906, ISSN: 1433-7851, DOI: 10.1002/anie.200461337
Attorney, Agent or Firm:
CURRADO, Luisa et al. (Viale Della Tecnica 205, Roma, IT)
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