Title:
ASSESSMENT OF RISK OF ANEUPLOIDY
Document Type and Number:
WIPO Patent Application WO/2014/155105
Kind Code:
A3
Abstract:
The present disclosure relates generally to methods and materials for use in detecting abnormalities of the number of whole chromosomes or chromosome regions (aneuploidy). It has particular utility for assessing the risk of aneuploidy of eggs (i.e., oocytes), fertilised eggs or embryos developed therefrom in the context of in vitro fertilisation.
Inventors:
HANDYSIDE ALAN (GB)
Application Number:
PCT/GB2014/050955
Publication Date:
December 18, 2014
Filing Date:
March 26, 2014
Export Citation:
Assignee:
BLUEGNOME LTD (GB)
International Classes:
C12Q1/68; C12N5/073
Other References:
D. CHRISTOPIKOU ET AL: "Polar body analysis by array comparative genomic hybridization accurately predicts aneuploidies of maternal meiotic origin in cleavage stage embryos of women of advanced maternal age", HUMAN REPRODUCTION, vol. 28, no. 5, 10 March 2013 (2013-03-10), pages 1426 - 1434, XP055146306, ISSN: 0268-1161, DOI: 10.1093/humrep/det053
ALAN H HANDYSIDE ET AL: "Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation", EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 20, no. 7, 1 July 2012 (2012-07-01), pages 742 - 747, XP055146383, ISSN: 1018-4813, DOI: 10.1038/ejhg.2011.272
ALAN H. HANDYSIDE: "Molecular origin of female meiotic aneuploidies", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - MOLECULAR BASIS OF DISEASE, vol. 1822, no. 12, 1 December 2012 (2012-12-01), pages 1913 - 1920, XP055146382, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2012.07.007
ALTARESCU G ET AL: "Gene location matters: polar body analysis has limited informativity in centromeric genes", REPRODUCTIVE BIOMEDICINE ONLINE, REPRODUCTIVE HEALTHCARE LTD, GB, vol. 18, 1 January 2009 (2009-01-01), pages S - 10, XP027051939, ISSN: 1472-6483, [retrieved on 20090101]
A. H. HANDYSIDE ET AL: "Karyomapping: a universal method for genome wide analysis of genetic disease based on mapping crossovers between parental haplotypes", JOURNAL OF MEDICAL GENETICS, vol. 47, no. 10, 25 October 2009 (2009-10-25), pages 651 - 658, XP055146321, ISSN: 0022-2593, DOI: 10.1136/jmg.2009.069971
ALAN H HANDYSIDE ET AL: "Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation", EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 20, no. 7, 1 July 2012 (2012-07-01), pages 742 - 747, XP055146383, ISSN: 1018-4813, DOI: 10.1038/ejhg.2011.272
ALAN H. HANDYSIDE: "Molecular origin of female meiotic aneuploidies", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - MOLECULAR BASIS OF DISEASE, vol. 1822, no. 12, 1 December 2012 (2012-12-01), pages 1913 - 1920, XP055146382, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2012.07.007
ALTARESCU G ET AL: "Gene location matters: polar body analysis has limited informativity in centromeric genes", REPRODUCTIVE BIOMEDICINE ONLINE, REPRODUCTIVE HEALTHCARE LTD, GB, vol. 18, 1 January 2009 (2009-01-01), pages S - 10, XP027051939, ISSN: 1472-6483, [retrieved on 20090101]
A. H. HANDYSIDE ET AL: "Karyomapping: a universal method for genome wide analysis of genetic disease based on mapping crossovers between parental haplotypes", JOURNAL OF MEDICAL GENETICS, vol. 47, no. 10, 25 October 2009 (2009-10-25), pages 651 - 658, XP055146321, ISSN: 0022-2593, DOI: 10.1136/jmg.2009.069971
Attorney, Agent or Firm:
MURGITROYD & COMPANY (165-169 Scotland StreetGlasgow,Strathclyde, G5 8PL, GB)
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