Title:
ASTATINE SOLUTION AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2019/131998
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an astatine solution that can be used in radionuclide therapy for the treatment of thyroid disease or the like, and a method for producing the same. The present invention provides: a method for producing a solution including 211At- (astatinide ion) using 211At obtained by nuclear reaction as a raw material, wherein the method for producing a solution including 211At- (astatinide ion) at high radiochemical purity includes a step for adding a reducing agent to a solution including impurities derived from 211At; and a solution including 211At- (astatinide ion) at a radiochemical purity of 30% or higher.
Inventors:
SHIRAKAMI YOSHIFUMI (JP)
WATABE TADASHI (JP)
KANEDA KAZUKO (JP)
SHIMOSEGAWA EKU (JP)
SHINOHARA ATSUSHI (JP)
HATAZAWA JUN (JP)
WATABE TADASHI (JP)
KANEDA KAZUKO (JP)
SHIMOSEGAWA EKU (JP)
SHINOHARA ATSUSHI (JP)
HATAZAWA JUN (JP)
Application Number:
PCT/JP2018/048442
Publication Date:
July 04, 2019
Filing Date:
December 28, 2018
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K51/00; A61K9/08; A61K47/22; A61P5/14; A61P35/00
Domestic Patent References:
| WO2017089492A1 | 2017-06-01 |
Foreign References:
| JP2017528512A | 2017-09-28 | |||
| JP2017507929A | 2017-03-23 | |||
| JP2017255109A | 2017-12-29 |
Other References:
CARLIN S. ET AL.: "In Vitro Cytotoxicity of 211At-Astatide and 131I- Iodide to Glioma Tumor Cells Expressing the Sodium/Iodide Symporter", THE JOURNAL OF NUCLEAR MEDICINE, vol. 44, no. 11, 2003, pages 1827 - 1838, XP55623134
SPETZ J ET AL., CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, vol. 28, no. 9, 2013, pages 657 - 664
CARLIN S ET AL., THE JOURNAL OF NUCLEAR MEDICINE, vol. 44, no. 11, November 2003 (2003-11-01), pages 1827 - 1838
ATSUSHI SHIOZAKI ET AL.: "Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer", GASTRIC CANCER, 6 September 2018 (2018-09-06), Retrieved from the Internet
SPETZ J ET AL., CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, vol. 28, no. 9, 2013, pages 657 - 664
CARLIN S ET AL., THE JOURNAL OF NUCLEAR MEDICINE, vol. 44, no. 11, November 2003 (2003-11-01), pages 1827 - 1838
ATSUSHI SHIOZAKI ET AL.: "Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer", GASTRIC CANCER, 6 September 2018 (2018-09-06), Retrieved from the Internet
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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