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Document Type and Number:
WIPO Patent Application WO/2010/021093
Kind Code:
Provided are a novel asymmetric organic catalyst with which it is possible to realize a high optically-active yield when said catalyst is used in a small amount, and a method for producing a compound using the same. The asymmetric organic catalyst is for addition reactions or condensation reactions and is formed from an optically active diaminocyclohexanecarboxylic acid represented by formula (1), or Brønsted acid salt thereof. (In the formula, one of R1 and R2 is a hydrogen atom and the other is an acyl group, and R3 is an alkoxy, aryloxy, aralkyloxy, amino, alkylamino, or dialkylamino group.  * is an asymmetric carbon atom, and R1HN- and R2HN- have the same configuration on the asymmetric carbon atom.)

NAKAYAMA, Keiji (LIMITED 1-12-1, Shinomiya, Hiratsuka-sh, Kanagawa 14, 〒2540014, JP)
Application Number:
Publication Date:
February 25, 2010
Filing Date:
August 04, 2009
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DAIICHI SANKYO COMPANY, LIMITED (3-5-1, Nihonbashi Honcho Chuo-k, Tokyo 26, 〒1038426, JP)
第一三共株式会社 (〒26 東京都中央区日本橋本町三丁目5番1号 Tokyo, 〒1038426, JP)
International Classes:
B01J31/04; C07C45/72; C07C49/493; C07C49/497; C07C49/517; C07C201/12; C07C205/45; C07C253/30; C07C255/56; C07D319/06; C07B53/00; C07B61/00; C07C309/18
Foreign References:
Other References:
LUO SANZHONG ET AL.: "Highly Enantioselective Direct syn- and anti-Aldol Reactions of Dihydroxyacetones Catalyzed by Chiral Primary Amine Catalysts", ORG. LETT., vol. 10, no. 4, 21 February 2008 (2008-02-21), pages 653 - 656
GUIZZETTI STEFANIA ET AL.: "Enantioselective Direct Aldol Reaction "on Water" Promoted by Chiral Organic Catalysts", ORG. LETT., vol. 9, no. 7, 29 March 2007 (2007-03-29), pages 1247 - 1250
NAKADAI MASAKAZU ET AL.: "Diversity-based strategy for discovery of environmentally benign organocatalyst:diamine-protonic acid catalysts for asymmetric direct aldol reaction", TETRAHEDRON, vol. 58, no. 41, 7 October 2002 (2002-10-07), pages 8167 - 8177
NAKAYAMA KEIJI ET AL.: "Complete Switch of Procuct Selectivity in Asymmetric Direct Aldol Reaction with Two Different Chiral Orgnocatalysts from a Common Chiral Source", J. AM. CHEM. SOC., vol. 130, no. 52, 31 December 2008 (2008-12-31), pages 17666 - 17667
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (Kyodo Bldg, 3-6 Nihonbashiningyocho 1-chome, Chuo-k, Tokyo 13, 〒1030013, JP)
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