Title:
ASYMMETRIC SIRNA FOR INHIBITING EXPRESSION OF SNAI1
Document Type and Number:
WIPO Patent Application WO/2020/122534
Kind Code:
A1
Abstract:
The present invention relates to asymmetric siRNA for inhibiting the expression of SNAI1 (Snail1), and a use thereof and, more specifically, to: asymmetric siRNA, which comprises an antisense strand comprising a sequence complementary to mRNA encoding SNAI1, and a sense strand forming a complementary bond with the antisense strand; and a pharmaceutical composition for preventing or treating fibrosis or cancer, containing the asymmetric siRNA. The present invention allows the selection of asymmetric siRNA which modulates transcription factor SNAI1 (Snail1), a key factor of EMT closely related to tissue regeneration and fibrosis and cancer occurrence and metastasis, by functioning to inhibit the expression of E-cadherin, and allows chemical modification so that cytotoxicity caused by a carrier is removed and more efficient inhibition of gene expression in vivo is enabled, thereby being effectively usable as an agent for preventing or treating fibrosis or cancer.
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Inventors:
LEE DONG-KI (KR)
PARK JUNE HYUN (KR)
PARK JUNE HYUN (KR)
Application Number:
PCT/KR2019/017332
Publication Date:
June 18, 2020
Filing Date:
December 10, 2019
Export Citation:
Assignee:
OLIX PHARMACEUTICALS INC (KR)
International Classes:
C12N15/113; A61K31/7088; A61P35/00
Foreign References:
| KR20180128423A | 2018-12-03 | |||
| US20060134787A1 | 2006-06-22 |
Other References:
HEMMATZADEH, M. ET AL.: "Snail-1 Silencing by siRNA Inhibits Migration of TE-8 Esophageal Cancer Cells Through Downregulation of Metastasis-Related Genes Adv", ADV PHARM BULL, vol. 8, no. 3, 29 August 2018 (2018-08-29), pages 437 - 445, XP055722199
DATABASE Nucleotide 22 November 2018 (2018-11-22), "Homo sapiens snail family transcriptional repressor 1 (SNAI1), mRNA", XP055722202, retrieved from NCBI Database accession no. NM_005985.4
MUSAVI SHENAS, S. M. H. ET AL.: "SiRNA-mediated silencing of Snail-1 induces apoptosis and alters micro RNA expression in human urinary bladder cancer cell line", ARTIF. CELLS NANOMED. BIOTECHNOL, vol. 45, no. 5, 4 July 2017 (2017-07-04), pages 969 - 974, XP055722201
DATABASE Nucleotide 22 November 2018 (2018-11-22), "Homo sapiens snail family transcriptional repressor 1 (SNAI1), mRNA", XP055722202, retrieved from NCBI Database accession no. NM_005985.4
MUSAVI SHENAS, S. M. H. ET AL.: "SiRNA-mediated silencing of Snail-1 induces apoptosis and alters micro RNA expression in human urinary bladder cancer cell line", ARTIF. CELLS NANOMED. BIOTECHNOL, vol. 45, no. 5, 4 July 2017 (2017-07-04), pages 969 - 974, XP055722201
Attorney, Agent or Firm:
Y.P.LEE,MOCK & PARTNERS et al. (KR)
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