Title:
ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2013/126495
Kind Code:
A3
Abstract:
Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds.
Inventors:
CONNOLLY TERRENCE J (US)
RUCHELMAN ALEXANDER L (US)
LEONG WILLIAM W (US)
RUCHELMAN ALEXANDER L (US)
LEONG WILLIAM W (US)
Application Number:
PCT/US2013/027010
Publication Date:
October 31, 2013
Filing Date:
February 21, 2013
Export Citation:
Assignee:
CELGENE CORP (US)
International Classes:
C07C315/04; C07B53/00; C07C317/18; C07C317/28
Foreign References:
| CA2761845A1 | 2010-11-18 | |||
| US20100168475A1 | 2010-07-01 |
Other References:
YI HSIAO, ET AL.: "Highly efficient synthesis of beta-amino acid derivatives via asymmetric hydrogenation of unprotected enamines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 32, 21 July 2004 (2004-07-21), American Chemical Society, Washington, DC, US, pages 9918 - 9919, XP002339712, ISSN: 0002-7863, DOI: 10.1021/ja047901i
E.J. COREY, ET AL.: "A stable and easily prepared catalyst for the enantioselective reduction of ketones. Applications to multistep syntheses", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 109, no. 25, December 1987 (1987-12-01), American Chemical Society, Washington, DC, US, pages 7925 - 7926, XP002177843, ISSN: 0002-7863, DOI: 10.1021/ja00259a075
CHU-YI YU, ET AL.: "A concise synthesis of homochiral sedamines and related alkaloids. A new reductive application of Jacobsen's catalyst", TETRAHEDRON LETTERS, vol. 40, no. 36, 3 September 1999 (1999-09-03), Elsevier Science Publishers, Amsterdam, NL, pages 6665 - 6668, XP004173985, ISSN: 0040-4039, DOI: 10.1016/s0040-4039(99)01341-6
M.J. BURK, ET AL.: "Enantioselective hydrogenation of the C:N group: a catalytic asymmetric reductive amination procedure", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 114, no. 15, July 1992 (1992-07-01), American Chemical Society, Washington, DC, US, pages 6266 - 6267, XP055075845, ISSN: 0002-7863, DOI: 10.1021/ja00041a067
E.J. COREY, ET AL.: "A stable and easily prepared catalyst for the enantioselective reduction of ketones. Applications to multistep syntheses", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 109, no. 25, December 1987 (1987-12-01), American Chemical Society, Washington, DC, US, pages 7925 - 7926, XP002177843, ISSN: 0002-7863, DOI: 10.1021/ja00259a075
CHU-YI YU, ET AL.: "A concise synthesis of homochiral sedamines and related alkaloids. A new reductive application of Jacobsen's catalyst", TETRAHEDRON LETTERS, vol. 40, no. 36, 3 September 1999 (1999-09-03), Elsevier Science Publishers, Amsterdam, NL, pages 6665 - 6668, XP004173985, ISSN: 0040-4039, DOI: 10.1016/s0040-4039(99)01341-6
M.J. BURK, ET AL.: "Enantioselective hydrogenation of the C:N group: a catalytic asymmetric reductive amination procedure", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 114, no. 15, July 1992 (1992-07-01), American Chemical Society, Washington, DC, US, pages 6266 - 6267, XP055075845, ISSN: 0002-7863, DOI: 10.1021/ja00041a067
Attorney, Agent or Firm:
INSOGNA, Anthony, M. et al. (222 East 41st StreetNew York, NY, US)
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