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Title:
ASYMMETRIC UREAS AND MEDICAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/116176
Kind Code:
A3
Abstract:
Compounds of Formula (I), known as asymmetric ureas, are useful for preventing and/or treating diseases that are pathophysiologic ally related to the ghrelin receptor in a subject. Method of treating a disease that is mediated by the ghrelin receptor, comprising administering to said subject a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or adduct thereof. Pharmaceutical compositions for preventing and/or treating diseases which are pathophysiologically related to ghrelin receptor in a subject, comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or adduct thereof, and one or more pharmaceutically acceptable excipients.

Inventors:
GARCIA RUBIO, Silvina (7 Bellflower Ct, Princeton, NJ, 08540, US)
PIETRA, Claudio (Via Scalabrini 56, Como, IT)
GIULIANO, Claudio (Via Prudenziana 28/A, Como, IT)
LI, Zhigang (Room 601, No768 Meihua RoadPudong Distric, Shanghai 4, 201204, CN)
Application Number:
US2012/026315
Publication Date:
April 24, 2014
Filing Date:
February 23, 2012
Export Citation:
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Assignee:
HELSINN HEALTHCARE SA (Via Pian Scairolo 9, Lugano/Pazzallo, Lugano/Pazzallo, CH)
GARCIA RUBIO, Silvina (7 Bellflower Ct, Princeton, NJ, 08540, US)
PIETRA, Claudio (Via Scalabrini 56, Como, IT)
GIULIANO, Claudio (Via Prudenziana 28/A, Como, IT)
LI, Zhigang (Room 601, No768 Meihua RoadPudong Distric, Shanghai 4, 201204, CN)
International Classes:
C07C275/06; C07C275/26; C07D213/00
Foreign References:
US20080300251A12008-12-04
US20050014794A12005-01-20
US20090239841A12009-09-24
US20060161006A12006-07-20
US20060040906A12006-02-23
Other References:
See also references of EP 2678017A4
Attorney, Agent or Firm:
SULLIVAN, Clark, G. (Arnall Golden Gregory LLP, 171 17th Street NWSuite 210, Atlanta GA, 30363, US)
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