Title:
ASYMMETRICAL HYDROGENATION REACTION OF KETONIC ACID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2016/041351
Kind Code:
A1
Abstract:
The present invention relates to the technical field of organic chemistry, specifically an asymmetrical hydrogenation reaction of an α-ketonic acid compound, the scheme being as shown by formula (I), wherein R1 is a phenyl, a substituted phenyl, a naphthyl, a substituted naphthyl, a C1-C6 alkyl or an aralkyl; the substituent is a C1-C6 alkyl, a C1-C6 alkoxy, a halogen; and the number of the substituents is 1-3. M is a chiral spiro-pyridylamidophosphine ligand iridium complex having the structure (II), wherein R is hydrogen, 3-methyl, 4-tBu or 6-methyl.
Inventors:
YAN PUCHA (CN)
LI YUANQIANG (CN)
CHE DAQING (CN)
ZHANG XIANGDONG (CN)
CHEN KANG (CN)
YAN YONGLIANG (CN)
LI YUANQIANG (CN)
CHE DAQING (CN)
ZHANG XIANGDONG (CN)
CHEN KANG (CN)
YAN YONGLIANG (CN)
Application Number:
PCT/CN2015/077660
Publication Date:
March 24, 2016
Filing Date:
April 28, 2015
Export Citation:
Assignee:
ZHEJIANG JIUZHOU PHARM CO LTD (CN)
International Classes:
C07C51/367; B01J31/24; C07C59/01; C07C59/11; C07C59/48; C07C59/50; C07C59/56; C07C59/64; C07F9/58
Domestic Patent References:
| WO2012065571A1 | 2012-05-24 |
Foreign References:
| CN1112563A | 1995-11-29 | |||
| CN101671365A | 2010-03-17 | |||
| CN1439643A | 2003-09-03 |
Other References:
See also references of EP 3196185A4
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