Title:
ATG ANALOGUE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/090717
Kind Code:
A1
Abstract:
Provided are an ATG analogue, a preparation method therefor and a use thereof, the specific structure of the ATG analogue is as shown in the following three general formulae: formula (I), formula (II), and formula (III) wherein X/Y/Z can be respectively selected from C, N, S and O, and R1, R2, R3, R4 and R5 are each respectively selected from: H, a CH3 group, an aliphatic or aromatic hydrocarbon group, a nitro group, a phosphate group, a sulphide group, a sulphone group, a nitrile group, a heterocyclic group, a borate or boric acid group, an ester group and an amine group. The ATG analogue provided by the present invention has better water solubility and has an effect of preventing being decomposed in primary metabolism.
Inventors:
ZHONG YIFEI (CN)
HE CIJIANG (US)
DAS BHASKAR (US)
LIU RUIJIE (US)
HE CIJIANG (US)
DAS BHASKAR (US)
LIU RUIJIE (US)
Application Number:
PCT/CN2017/102936
Publication Date:
May 24, 2018
Filing Date:
September 22, 2017
Export Citation:
Assignee:
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE (CN)
International Classes:
C07F5/02; A61K31/69; A61P43/00; C07C43/23; C07C49/255; C07C59/64; C07C59/74; C07D307/33
Domestic Patent References:
| WO2012112670A1 | 2012-08-23 |
Foreign References:
| CN106800569A | 2017-06-06 | |||
| CN102046179A | 2011-05-04 | |||
| CN104447234A | 2015-03-25 | |||
| CN103930126A | 2014-07-16 |
Other References:
DAS, BHASKAR C.: "Design and synthesis of 3, 5-disubstituted boron-con- taining 1, 2, 4-oxadiazoles as potential combretastatin A-4 ( CA -4) analog s", TETRAHEDRON LETTERS, vol. 53, no. 31, 30 December 2012 (2012-12-30)
MIURA, TOMOYA: "Facile Synthesis of 2, 5-Disubstituted Thiazoles from Terminal Alkynes, Sulfonyl Azides, and Thionoesters", ORGANIC LETTERS, vol. 17, no. 10, 30 April 2015 (2015-04-30), pages 2454 - 2457, XP055605554, DOI: 10.1021/acs.orglett.5b00960
MIURA, TOMOYA: "Facile Synthesis of 2, 5-Disubstituted Thiazoles from Terminal Alkynes, Sulfonyl Azides, and Thionoesters", ORGANIC LETTERS, vol. 17, no. 10, 30 April 2015 (2015-04-30), pages 2454 - 2457, XP055605554, DOI: 10.1021/acs.orglett.5b00960
Attorney, Agent or Firm:
SHANGHAI CPTO INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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