Title:
ATOMIZATION METHOD FOR TREPROSTINIL AEROSOL INHALANT FOR TREATMENT OF PULMONARY HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2023/087345
Kind Code:
A1
Abstract:
A preparation method for atomizing a treprostinil aerosol inhalant for treatment of pulmonary hypertension. According to the principle that aerosol is formed in a high-temperature state of a drug, treprostinil is applied onto a heating piece of a drug inhaler; gaseous treprostinil is formed by means of heating and is quickly condensed to form aerosol; and the aerosol is inhaled into a lung by means of a gas path and directly acts on a receptor in a pulmonary artery blood vessel. The present invention quickly takes effects, directly acts on a target site, and is small in dosage, quick in metabolism, and low in dosage of a drug distributed to other organs of a human body.
Inventors:
LI XIAOYI (CN)
DAI XIANGRONG (CN)
YIN LEI (CN)
DAI XIANGRONG (CN)
YIN LEI (CN)
Application Number:
PCT/CN2021/132791
Publication Date:
May 25, 2023
Filing Date:
November 24, 2021
Export Citation:
Assignee:
ZHAOKE PHARMACEUTICAL GUANGZHOU CO LTD (CN)
International Classes:
A61K9/72; A61K31/192; A61M11/04; A61P9/12; A61P11/00
Foreign References:
| US20040105819A1 | 2004-06-03 | |||
| US20210046259A1 | 2021-02-18 | |||
| US20040099269A1 | 2004-05-27 | |||
| US20070122353A1 | 2007-05-31 | |||
| CN107750177A | 2018-03-02 | |||
| CN1514719A | 2004-07-21 | |||
| US20080200449A1 | 2008-08-21 |
Other References:
ARI ARZU, FINK JAMES B: "Recent advances in aerosol devices for the delivery of inhaled medications", EXPERT OPINION ON DRUG DELIVERY, INFORMA HEALTHCARE, GB, vol. 17, no. 2, 1 February 2020 (2020-02-01), GB , pages 133 - 144, XP093067063, ISSN: 1742-5247, DOI: 10.1080/17425247.2020.1712356
Attorney, Agent or Firm:
BEIJING EASTKING PATENT AGENT FIRM (CN)
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