Title:
ATTENUATED CHIMERIC FLAVIVIRUS BEARING ATTENUATED JAPANESE ENCEPHALITIS VIRUS GENE AS BACKBONE
Document Type and Number:
WIPO Patent Application WO/2006/068307
Kind Code:
A1
Abstract:
A nucleic acid molecule comprising nucleotide sequences encoding a capsid protein, a premembrane protein and a non-structural protein of Japanese encephalitis virus and a nucleotide sequence encoding an envelope protein of a second flavivirus, wherein the nucleotide sequence encoding the premembrane protein and/or the non-structural protein of Japanese encephalitis virus has a nucleotide mutation therein which can cause at least one amino acid mutation capable of attenuating a virus.
Inventors:
MORITA KOUICHI (JP)
NABESHIMA TAKESHI (JP)
MIYAKE SHINICHI (JP)
ONISHI TOSHIYUKI (JP)
FUKUYA ISAO (JP)
ISHIKAWA TOYOKAZU (JP)
GODA HIDEO (JP)
ISHIBASHI MASAHIDE (JP)
TAKAHASHI MICHIAKI (JP)
NABESHIMA TAKESHI (JP)
MIYAKE SHINICHI (JP)
ONISHI TOSHIYUKI (JP)
FUKUYA ISAO (JP)
ISHIKAWA TOYOKAZU (JP)
GODA HIDEO (JP)
ISHIBASHI MASAHIDE (JP)
TAKAHASHI MICHIAKI (JP)
Application Number:
PCT/JP2005/024161
Publication Date:
June 29, 2006
Filing Date:
December 22, 2005
Export Citation:
Assignee:
UNIV OSAKA RES FOUND (JP)
MORITA KOUICHI (JP)
NABESHIMA TAKESHI (JP)
MIYAKE SHINICHI (JP)
ONISHI TOSHIYUKI (JP)
FUKUYA ISAO (JP)
ISHIKAWA TOYOKAZU (JP)
GODA HIDEO (JP)
ISHIBASHI MASAHIDE (JP)
TAKAHASHI MICHIAKI (JP)
MORITA KOUICHI (JP)
NABESHIMA TAKESHI (JP)
MIYAKE SHINICHI (JP)
ONISHI TOSHIYUKI (JP)
FUKUYA ISAO (JP)
ISHIKAWA TOYOKAZU (JP)
GODA HIDEO (JP)
ISHIBASHI MASAHIDE (JP)
TAKAHASHI MICHIAKI (JP)
International Classes:
C12N15/09; A61K39/12; A61K39/295; A61P31/12; C12N7/00; C12N7/04
Foreign References:
| JPH06511150A | 1994-12-15 | |||
| JP2003523189A | 2003-08-05 |
Other References:
YOSHIDA I. ET AL.: "Establishment of an attenuated ML-17 strain of Japanese encephalitis virus", BIKEN J., vol. 24, no. 1-2, 1981, pages 47 - 67, XP002999439
NI H. ET AL.: "Molecular basis of attenuation of neurovirulence of wild-type Japanese encephalitis virus strain SA14", J. GEN. VIROL., vol. 76, no. 2, 1995, pages 409 - 413, XP000885551
AIHARA S. ET AL.: "Identification of mutations that occured on the genome of Japanese encephalitis virus during the attenuation process", VIRUS GENES, vol. 5, no. 2, 1991, pages 95 - 109, XP002999440
See also references of EP 1840214A4
SUMIYOSHI ET AL., VIROLOGY, vol. 161, 1987, pages 497 - 510
WENGLER ET AL., VIROLOGY, vol. 147, 1985, pages 264 - 274
MASON ET AL., VIROLOGY, vol. 161, 1987, pages 262 - 267
DEUBEL ET AL., VIROLOGY, vol. 155, 1986, pages 365 - 377
GRUENBERG ET AL., J. GEN. VIROL., vol. 69, 1988, pages 1391 - 1398
HAHN ET AL., VIROLOGY, vol. 162, 1988, pages 167 - 180
OSATOMI ET AL., VIRUS GENES, vol. 2, 1988, pages 99 - 108
MACKOW ET AL., VIROLOGY, vol. 159, 1987, pages 217 - 228
ZHAO ET AL., VIROLOGY, vol. 155, 1986, pages 77 - 88
RICE ET AL., SCIENCE, vol. 229, 1985, pages 726 - 733
TRENT ET AL., VIROLOGY, vol. 156, 1987, pages 293 - 304
MANDL ET AL., VIROLOGY, vol. 166, 1988, pages 197 - 205
COIA ET AL., J. GEN. VIROL., vol. 69, 1988, pages 1 - 21
VENUGOPAL ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 75, 1994, pages 227 - 232
KUNO ET AL., JOURNAL OF VIROLOGY, vol. 72, 1998, pages 73 - 83
DALGARNO ET AL., J. MOL. BIOL., vol. 187, 1986, pages 309 - 323
LIN ET AL., VIROLOGY, vol. 313, 2003, pages 81 - 90
LI ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 85, 2004, pages 1619 - 1624
GRITSUN ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 74, 1993, pages 287 - 291
KUNO ET AL., AM. J. TROP. MED. HYG., vol. 65, pages 671 - 676
MORITA ET AL., VIROLOGY, vol. 287, 2001, pages 417 - 426
NI H. ET AL.: "Molecular basis of attenuation of neurovirulence of wild-type Japanese encephalitis virus strain SA14", J. GEN. VIROL., vol. 76, no. 2, 1995, pages 409 - 413, XP000885551
AIHARA S. ET AL.: "Identification of mutations that occured on the genome of Japanese encephalitis virus during the attenuation process", VIRUS GENES, vol. 5, no. 2, 1991, pages 95 - 109, XP002999440
See also references of EP 1840214A4
SUMIYOSHI ET AL., VIROLOGY, vol. 161, 1987, pages 497 - 510
WENGLER ET AL., VIROLOGY, vol. 147, 1985, pages 264 - 274
MASON ET AL., VIROLOGY, vol. 161, 1987, pages 262 - 267
DEUBEL ET AL., VIROLOGY, vol. 155, 1986, pages 365 - 377
GRUENBERG ET AL., J. GEN. VIROL., vol. 69, 1988, pages 1391 - 1398
HAHN ET AL., VIROLOGY, vol. 162, 1988, pages 167 - 180
OSATOMI ET AL., VIRUS GENES, vol. 2, 1988, pages 99 - 108
MACKOW ET AL., VIROLOGY, vol. 159, 1987, pages 217 - 228
ZHAO ET AL., VIROLOGY, vol. 155, 1986, pages 77 - 88
RICE ET AL., SCIENCE, vol. 229, 1985, pages 726 - 733
TRENT ET AL., VIROLOGY, vol. 156, 1987, pages 293 - 304
MANDL ET AL., VIROLOGY, vol. 166, 1988, pages 197 - 205
COIA ET AL., J. GEN. VIROL., vol. 69, 1988, pages 1 - 21
VENUGOPAL ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 75, 1994, pages 227 - 232
KUNO ET AL., JOURNAL OF VIROLOGY, vol. 72, 1998, pages 73 - 83
DALGARNO ET AL., J. MOL. BIOL., vol. 187, 1986, pages 309 - 323
LIN ET AL., VIROLOGY, vol. 313, 2003, pages 81 - 90
LI ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 85, 2004, pages 1619 - 1624
GRITSUN ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 74, 1993, pages 287 - 291
KUNO ET AL., AM. J. TROP. MED. HYG., vol. 65, pages 671 - 676
MORITA ET AL., VIROLOGY, vol. 287, 2001, pages 417 - 426
Attorney, Agent or Firm:
Takashima, Hajime (1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, JP)
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