Title:
ATTENUATED HERPES SIMPLEX VIRUS TYPE-2, VECTORS THEREOF AND IMMUNOGENIC COMPOSITIONS THEREOF
Document Type and Number:
WIPO Patent Application WO2006004878
Kind Code:
A9
Abstract:
The present invention broadly relates to the attenuation of herpes simplex virus type 2 (HSV-2). More particularly, the invention relates to the identification of mutations in the HSV-2 UL24 gene which attenuate the pathogenicity of HSV vectors in mammals and immunogenic compositions thereof.
Inventors:
VISALLI ROBERT J (US)
KOWALSKI JACEK (US)
NATUK ROBERT J (US)
BLAKENEY SUSAN J (US)
KOWALSKI JACEK (US)
NATUK ROBERT J (US)
BLAKENEY SUSAN J (US)
Application Number:
PCT/US2005/023185
Publication Date:
March 09, 2006
Filing Date:
June 28, 2005
Export Citation:
Assignee:
WYETH CORP (US)
VISALLI ROBERT J (US)
KOWALSKI JACEK (US)
NATUK ROBERT J (US)
BLAKENEY SUSAN J (US)
VISALLI ROBERT J (US)
KOWALSKI JACEK (US)
NATUK ROBERT J (US)
BLAKENEY SUSAN J (US)
International Classes:
C12N7/04; A61K38/00; A61K39/245; C12N5/10
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