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Title:
ATTENUATED SALMONELLA MUTANTS WHEREIN ADHESIN OF BOVINE PATHOGENIC ESCHERICHIA COLI IS TRANSFORMED, AND VACCINE COMPOSITION FOR PREVENTING AND TREATING BOVINE COLIBACILLOSIS AND SALMONELLOSIS COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2011/025344
Kind Code:
A2
Abstract:
The present invention provides Salmonella mutants which comprise an adhesin gene of bovine pathogenic Escherichia coli, and are transformed into attenuated Salmonella mutants wherein asd, lon and cpxR genes are deleted; and a vaccine composition for preventing and treating bovine Colibacillosis and Salmonellosis comprising the same. The Salmonella mutants of the present invention efficiently deliver an antigen derived from Escherichia coli into bovine mucosa lymphoid tissues and induce powerful mucosal immunity, and enable the production of the associated vaccine and mass innoculation. In addition, the Salmonella mutants of the present invention allow the innoculation cost and the side effects such as pain, inflammation or the like to be reduced. The production and storage of the Salmonella mutants of the present invention are easy and thus economical. Therefore, the Salmonella mutants of the present invention prevent infections by inducing immune responses against Salmonella and can be used as a polyvalent vaccine due to the inducement of immune responses against expressing exogenous antigens.

Inventors:
LEE, John Hwa (College of veterinary medicine, Chonbuk National University 664-14Deokjindong 1-ga, Deokjin-gu,Jeonju -Si, Jeollabuk-Do 561-756, 561-756, KR)
이존화 (전라북도 전주시 덕진구 덕진동1가 664-14번지 전북대학교 수의과대학, 561-756 Jeollabuk-Do, 561-756, KR)
JUNG, Gu-Nam (Hyundai Apt, Hyoja-dongWansan-gu, Jeonju-si, Jeollabuk-Do 560-885, 560-885, KR)
정구남 (전라북도 전주시 완산구 효자동 현대아파트 103동 1102호, 560-885 Jeollabuk-Do, 560-885, KR)
KIM, Eun-Sung (455 Hoseongdong 1-ga, Deokjin-gu Jeonju-si, Jeollabuk-do 561-211, 561-211, KR)
Application Number:
KR2010/005895
Publication Date:
March 03, 2011
Filing Date:
August 31, 2010
Export Citation:
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Assignee:
INDUSTRIAL COOPERATION FOUNDATION CHONBUK NATIONAL UNIVERSITY (3F Head Office Annexe, 664-14 Deokjindong 1-ga Deokjin-gu, Jeonju -Si, Jeollabuk-Do 561-191, 561-191, KR)
전북대학교 산학협력단 (전라북도 전주시 덕진구 덕진동 1가 664-14 본부별관 3층, 561-191 Jeollabuk-Do, 561-191, KR)
CHOLLABUK-DO PROVINCIAL GOVERNMENT (1 Hyoja-dong 3-ga, Wansan-gu Jeonju-si, Jeollabuk-do 560-761, 560-761, KR)
전라북도 (전라북도 전주시 완산구 효자동 3가 1번지, 560-761 Jeollabuk-do, 560-761, KR)
CHOONG ANG VACCINE LAB (59-3 Hwaam-dong, Yuseong-gu, Daejeon 305-348, 305-348, KR)
주식회사 중앙백신연구소 (대전광역시 유성구 화암동 59-3, 305-348 Daejeon, 305-348, KR)
LEE, John Hwa (College of veterinary medicine, Chonbuk National University 664-14Deokjindong 1-ga, Deokjin-gu,Jeonju -Si, Jeollabuk-Do 561-756, 561-756, KR)
이존화 (전라북도 전주시 덕진구 덕진동1가 664-14번지 전북대학교 수의과대학, 561-756 Jeollabuk-Do, 561-756, KR)
International Classes:
C12N15/31; A61P1/00; C12N15/09
Foreign References:
KR20080082156A2008-09-11
US20080286310A12008-11-20
Other References:
WARD, S. J. ET AL.: 'Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A' INFECT IMMUN vol. 67, no. 5, May 1999, pages 2145 - 2152
GUILLOBEL H. C. ET AL.: 'Immunization against the colonization factor antigen I of enterotoxigenic Escherichia coli by administration of abivalent Salmonella typhimurium aroA strain' BRAZ J MED BIOL RES vol. 31, no. 4, April 1998, pages 545 - 554
Attorney, Agent or Firm:
KIM, Soon Woong (209 KICOX Venture Center, 188-5 Guro-dong Guro-gu, Seoul 152-050, 152-050, KR)
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