Title:
ATTENUATED SWINE FEVER VIRUS LIVE MARKER VACCINE STRAIN AND VACCINE COMPOSITION FOR ORAL ADMINISTRATION USING SAME
Document Type and Number:
WIPO Patent Application WO/2017/116177
Kind Code:
A3
Abstract:
The present invention relates to an attenuated swine fever virus live marker vaccine strain and a vaccine composition for oral administration using same and, more particularly, to: an attenuated swine fever virus live marker vaccine strain (CSFV BErns attenuated C-P50) obtained by alternately and continuously culturing the conventional swine fever virus vaccine strain Flc-LOM-BErns between cells; a vaccine composition for oral administration comprising same; and a method for serologically differentiating between swine infected outdoors with swine fever virus and swine inoculated with the attenuated swine fever virus live marker vaccine strain. The safety of the attenuated swine fever virus live marker vaccine strain, CSFV BErns attenuated C-P50, according to the present invention has been enhanced by mitigating side effects, such as abortions/stillbirths in pregnant sows, which are problems of conventional swine fever virus vaccine strains. Also, the vaccine composition for oral administration according to the present invention can be made into bait dosage forms and easily consumed by swine and thus has solved the problem of conventional swine fever virus vaccines being used only as injections and thus difficult to be administered to fierce farmed wild boars and black pigs. Further, the serological differentiation method according to the present invention enables differentiation of the antigens and antibodies of swine infected outdoors with swine fever virus and swine inoculated with the attenuated swine fever virus live marker vaccine strain, CSFV BErns attenuated C-P50, and thus has the excellent effect of differentiating infected from vaccinated animals (DIVA).
Inventors:
AN DONG JUN (KR)
IM SUNG IN (KR)
CHOE SE EUN (KR)
CHO IN SOO (KR)
JEOUNG HYE YOUNG (KR)
SONG JAE YOUNG (KR)
KIM JAE JO (KR)
HAN GYOO HA (KR)
HYUN BANG HUN (KR)
KIM BYOUNG HAN (KR)
IM SUNG IN (KR)
CHOE SE EUN (KR)
CHO IN SOO (KR)
JEOUNG HYE YOUNG (KR)
SONG JAE YOUNG (KR)
KIM JAE JO (KR)
HAN GYOO HA (KR)
HYUN BANG HUN (KR)
KIM BYOUNG HAN (KR)
Application Number:
PCT/KR2016/015504
Publication Date:
March 08, 2018
Filing Date:
December 29, 2016
Export Citation:
Assignee:
REPUBLIC OF KOREA MANAGEMENT MINI OF AGRICULTURE FOOD AND RURAL AFFAIRS (KR)
International Classes:
C12N7/04; A61K39/00; A61K39/12; C12N15/85; G01N33/535; G01N33/569
Foreign References:
| KR20100121288A | 2010-11-17 | |||
| US20100104597A1 | 2010-04-29 | |||
| KR20140076137A | 2014-06-20 | |||
| JP2003523727A | 2003-08-12 | |||
| KR20140036262A | 2014-03-25 | |||
| KR101642727B1 | 2016-07-27 |
Attorney, Agent or Firm:
YOON, Dong Yol (KR)
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