Title:
AUREOBASIDINS
Document Type and Number:
WIPO Patent Application WO/1995/018147
Kind Code:
A1
Abstract:
Aureobasidins useful as a wide-spectrum antimycotic. They are cyclodepsipeptides composed of one hydroxy acid residue having group A1, three amino acid residues having groups C1, F1 and H1, four N-methylamino acid residues having groups B1, D1, G1 and I1, and one cyclic amino acid residue having E1. A representative example thereof is one wherein A1 is CH3CH2CH(CH3)-, B1 is (CH3)2CH-, C1 is benzyl, cyclohexylmethyl, p-fluorobenzyl, benzyloxymethyl, benzyloxybenzyl, methoxybenzyl, cyclohexylmethyloxybenzyl, etc., D1 is methyl, benzyl, hydroxymethyl, etc., E1 is propylene, F1 is CH3CH2CH(CH3)-, G1 is (CH3)2CH-, H1 is (CH3)2CHCH2-, and I1 is (CH3)2C(OH)-. They have excellent activities against not only candida but also cryptococcus and aspergillus.
Inventors:
KUROME TORU (JP)
INOUE TETSUYA (JP)
TAKESAKO KAZUTOH (JP)
INAMI KAORU (JP)
KATO IKUNOSHIN (JP)
INOUE TETSUYA (JP)
TAKESAKO KAZUTOH (JP)
INAMI KAORU (JP)
KATO IKUNOSHIN (JP)
Application Number:
PCT/JP1994/002201
Publication Date:
July 06, 1995
Filing Date:
December 26, 1994
Export Citation:
Assignee:
TAKARA SHUZO CO (JP)
KUROME TORU (JP)
INOUE TETSUYA (JP)
TAKESAKO KAZUTOH (JP)
INAMI KAORU (JP)
KATO IKUNOSHIN (JP)
KUROME TORU (JP)
INOUE TETSUYA (JP)
TAKESAKO KAZUTOH (JP)
INAMI KAORU (JP)
KATO IKUNOSHIN (JP)
International Classes:
C07K11/02; A61K38/00; (IPC1-7): C07K11/02; A61K38/15
Foreign References:
| JPH0665291A | 1994-03-08 | |||
| JPH0539204A | 1993-02-19 | |||
| JPH03220199A | 1991-09-27 |
Other References:
J. Antibiot., Vol. 46, No. 9 (1993), "Isolation, Structures, and Antifungal Activities of New Aureobasidins", pp. 1347-1354.
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