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Title:
AUREOLIC ACID DERIVATIVES, THE METHOD FOR PREPARATION THEREOF AND THE USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/009987
Kind Code:
A3
Abstract:
Aureolic acid derivatives, the method for preparation thereof and the uses thereof. The present invention provides a bacterial strain that produces compounds belonging to the aureolic acid family, which can be used in the treatment of cancer or neurological diseases.

Inventors:
NÚÑEZ GONZÁLEz, Luz Elena (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
MENÉNDEZ SÁNCHEZ, Nuria (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
GONZÁLEZ SABIN, Javier (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
MORÍS VARAS, Francisco (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
GARCÍA FERNÁNDEZ, Beatriz (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
PÉREZ SOLARES, María (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
FERNÁNDEZ BRAÑA, Alfredo (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
MÉNDEZ FERNÁNDEZ, María del Carmen (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
SALAS FERNÁNDEZ, José Antonio (Edificio Científico y Tecnológico, Campus "El Cristo", E-Oviedo, 33006, ES)
Application Number:
ES2010/070489
Publication Date:
July 21, 2011
Filing Date:
July 14, 2010
Export Citation:
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Assignee:
ENTRECHEM, S.L. (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
NÚÑEZ GONZÁLEz, Luz Elena (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
MENÉNDEZ SÁNCHEZ, Nuria (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
GONZÁLEZ SABIN, Javier (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
MORÍS VARAS, Francisco (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
GARCÍA FERNÁNDEZ, Beatriz (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
PÉREZ SOLARES, María (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
FERNÁNDEZ BRAÑA, Alfredo (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
MÉNDEZ FERNÁNDEZ, María del Carmen (Edificio Científico y Tecnológico, Campus "El Cristo", Oviedo, E-33006, ES)
SALAS FERNÁNDEZ, José Antonio (Edificio Científico y Tecnológico, Campus "El Cristo", E-Oviedo, 33006, ES)
International Classes:
C07H15/24; A61K31/704; A61P19/00; A61P19/08; A61P25/00; A61P35/00; C12N1/21; C12N9/10; C12N15/76; C12R1/465; C12R1/545
Domestic Patent References:
WO2008096028A12008-08-14
Foreign References:
US20050192432A12005-09-01
Other References:
PEREZ, M. ET AL.: 'Generation of New Derivatives of the Antitumor Antibiotic Mithramycin by Altering the Glycosylation Pattern through Combinatorial Biosynthesis' CHEMBIOCHEM 2008 vol. 9, no. ISSUE, pages 2295 - 2304., XP055008384
DATABASE CAPLUS [Online] GANN 1977 SAITO, T. ET AL.: 'Combination chemotherapy form solid tumors using 5-fluorouracil, chromomycin-A3, and prednisolone', XP007919511 Retrieved from STN Database accession no. 1977:561784
MENENDEZ, N. ET AL.: 'Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A3 by Streptomyces griseus ssp. griseus' MOLECULAR MICROBIOLOGY vol. 53, no. 3, 2004, pages 903 - 915, XP055008385
KAWANO, T. ET AL.: 'Isolation and structures of mono- and di-deacetyl chromomycin antibiotics 02-3D and 02-3G from Streptomyces avellaneus' THE JOURNALOF ANTIBIOTICS vol. XLIII, no. 1, 1990, pages 110 - 113, XP055008386
See also references of EP 2457921A2
Attorney, Agent or Firm:
ILLESCAS TABOADA, Manuel (Calle Recoletos nº 13 -5º Izq, Madrid, E-28001, ES)
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