AURISTATIN ANALOGUES AND THEIR CONJUGATES WITH CELL-BINDING MOLECULES

Title:

AURISTATIN ANALOGUES AND THEIR CONJUGATES WITH CELL-BINDING MOLECULES

Document Type and Number:

WIPO Patent Application WO/2015/151079

Kind Code:

A3

Abstract:

Provided are analogues of auristatins, in particular monomethyl auristatin F (MMAF), as cytotoxic agents, conjugates of such agents with a cell-binding agent, the preparation and the therapeutic uses of these cytotoxic agents and conjugates thereof to arrest or retard abnormal cell growth and /or proliferation.

More Like This:

WO/2009/138472	AMPHIPHILIC BLOCK COPOLYMERS FOR NUCLEIC ACID DELIVERY
JP5259030	Inorganic-polymer complex for controlled release of drug-containing compounds
WO/2016/144973	PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS

Inventors:

YANG QINGLIANG (CN)
ZHAO ROBERT Y (US)
YE HANGBO (CN)
GAI SHUN (CN)
JIA JUNXIANG (CN)
HUANG YUANYUAN (CN)
LI XING (CN)
GUO HUIHUI (CN)
XIE HONGSHENG (US)
LI WENJUN (CN)
ZHOU XIAOMAI (US)
YANG CHENGYU (CN)
ZHUO XIAOTAO (CN)
ZHAO LINYAO (CN)
CAO MINJUN (CN)
LIN CHEN (CN)
PENG JIE (CN)
YE ZHICANG (CN)
XU JUN (CN)

Application Number:

PCT/IB2015/054653

Publication Date:

May 06, 2016

Filing Date:

June 20, 2015

Export Citation:

Click for automatic bibliography generation Help

Assignee:

HANGZHOU DAC BIOTECH CO LTD (CN)

International Classes:

A61K47/48; A61K39/395; A61P35/00; C07K5/02

Domestic Patent References:

WO2009052431A2	2009-04-23
WO2014009774A1	2014-01-16
WO2014080251A1	2014-05-30
WO2005081711A2	2005-09-09
WO2012143497A2	2012-10-26

Download PDF:

View/Download PDF PDF Help

Previous Patent: HYDROPHILIC LINKERS FOR CONJUGATION

Next Patent: SPECIFIC CONJUGATION OF A CELL-BINDING MOLECULE