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Title:
AUTOANTIBODY PRODUCTION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2011/013470
Kind Code:
A1
Abstract:
Disclosed is an autoantibody production inhibitor which can inhibit an autoantibody specifically and can prevent or treat autoantibody autoimmune diseases effectively. The autoantibody production inhibitor is characterized by comprising, as an active ingredient, a fusion protein composed of a protein (X) and a protein (A), wherein the protein (X) comprises a segment which can be recognized by an autoantibody that causes autoantibody autoimmune diseases and the protein (A) comprises a fragment of an antibody heavy-chain constant-region which has an antibody-dependent cytotoxic activity.

Inventors:
HOMMA MASAYUKI (JP)
Application Number:
PCT/JP2010/060973
Publication Date:
February 03, 2011
Filing Date:
June 28, 2010
Export Citation:
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Assignee:
NIHON PHARMACEUTICAL CO LTD (JP)
HOMMA MASAYUKI (JP)
International Classes:
A61K39/00; A61K39/395; A61P5/14; A61P5/16; A61P7/04; A61P7/06; A61P21/04; A61P25/00; A61P37/02; A61P43/00; C07K14/705; C07K16/00; C07K19/00
Foreign References:
JPH02502538A1990-08-16
JP2008515926A2008-05-15
Other References:
ZOCHER M. ET AL.: "Specific depletion of autoreactive B lymphocytes by a recombinant fusion protein in vitro and in vivo.", INTERNATIONAL IMMUNOLOGY, vol. 15, no. 7, 2003, pages 789 - 796, XP001155918
MIHAYLOVA N. ET AL.: "Selective silencing of disease-associated B-lymphocytes by chimeric molecules targeting their Fc gamma IIb receptor.", INTERNATIONAL IMMUNOLOGY, vol. 20, no. 2, 2008, pages 165 - 175, XP002484435
TSOULOUFIS T. ET AL.: "Reconstitution of conformationally dependent epitopes on the N-terminal extracellular domain of the human muscle acetylcholine receptor alpha subunit expressed in Escherichia coli: implications for myasthenia gravis therapeutic approaches.", INTERNATIONAL IMMUNOLOGY, vol. 12, no. 9, 2000, pages 1255 - 1265, XP008148987
"Trends of clinical test studies for myasthenia gravis", NIPPON RINSHO, vol. 66, no. 6, pages 1155 - 1157
"High-dose therapy by immunoglobulin", SHINKEI CHIRYO, vol. 25, no. 6, pages 689 - 692
J. NEUROIMMUNOL, vol. 15, 1987, pages 185 - 94
See also references of EP 2465524A4
Attorney, Agent or Firm:
KAZAHAYA, Nobuaki et al. (JP)
Nobuaki Kazahaya (JP)
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