Title:
AUTOINDUCER COMPOUND TO IMPROVE THE PRODUCTIVITY OF NATAMYCIN PRODUCING STREPTOMYCES STRAINS
Document Type and Number:
WIPO Patent Application WO/2004/104206
Kind Code:
A1
Abstract:
The invention provides a compound of the formula (I). Furthermore, the invention provides a process for the production of a compound of formula (I). The present invention also provides a process for the production of natamycin by a Streptomyces strain comprising adding a composition comprising an auto inducer to the fermentation medium. The present invention furthermore provides the use of a compound of formula (I) in the manufacture of a product by fermentation of a Streptomyces strain. The present invention finally discloses a Streptomyces strain that is defective in natamycin production and that is capable of producing a compound of formula (I) wherein both R1 and R2 are hydrogen and a Streptomyces strain that is defective in production of a compound of formula (I) wherein both R1 and R2 are hydrogen and that is capable of producing natamycin in the presence of said compound.
Inventors:
MARTIN MARTIN JUAN FRANSISCO (ES)
RECIO PEREZ ELISEO (ES)
COLINA DELGADO ANGEL JOSE (ES)
FERNANDEZ APARICIO JESUS MANUE (ES)
RECIO PEREZ ELISEO (ES)
COLINA DELGADO ANGEL JOSE (ES)
FERNANDEZ APARICIO JESUS MANUE (ES)
Application Number:
PCT/EP2004/005187
Publication Date:
December 02, 2004
Filing Date:
May 13, 2004
Export Citation:
Assignee:
DSM IP ASSETS BV (NL)
MARTIN MARTIN JUAN FRANSISCO (ES)
RECIO PEREZ ELISEO (ES)
COLINA DELGADO ANGEL JOSE (ES)
FERNANDEZ APARICIO JESUS MANUE (ES)
MARTIN MARTIN JUAN FRANSISCO (ES)
RECIO PEREZ ELISEO (ES)
COLINA DELGADO ANGEL JOSE (ES)
FERNANDEZ APARICIO JESUS MANUE (ES)
International Classes:
C12N1/38; C12P1/04; C12P13/00; C12P17/04; C12P19/62; (IPC1-7): C12P13/00; C12P19/62; C12R1/465; C07C215/18; C07C219/06
Foreign References:
| GB2106498A | 1983-04-13 | |||
| US5686273A | 1997-11-11 | |||
| US5231014A | 1993-07-27 |
Other References:
HORINOUCHI, S ET AL: "A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus", MOLECULAR MICROBIOLOGY., vol. 12, no. 4, 1994, BLACKWELL SCIENTIFIC, OXFORD., GB, pages 859 - 864, XP008025042, ISSN: 0950-382X
DATABASE WPI Section Ch Week 200213, Derwent World Patents Index; Class C06, AN 2002-098073, XP002262853
HORINOUCHI, S ET AL: "Autoregulatory factors and communication in Actinomycetes", ANNUAL REVIEW OF MICROBIOLOGY., vol. 46, 1992, ANNUAL REVIEWS INC., PALO ALTO, CA., US, pages 377 - 398, XP008025175, ISSN: 0066-4227
HORINOUCHI, S ET AL: "Autoregulatory factors of secondary metabolism and morphogenesis in actinomycetes", CRC CRITICAL REVIEWS IN BIOTECHNOLOGY, vol. 10, no. 3, 1990, CRC PRESS, BOCA RATON, FL, US, pages 191 - 204, XP008025176, ISSN: 0738-8551
DATABASE WPI Section Ch Week 200213, Derwent World Patents Index; Class C06, AN 2002-098073, XP002262853
HORINOUCHI, S ET AL: "Autoregulatory factors and communication in Actinomycetes", ANNUAL REVIEW OF MICROBIOLOGY., vol. 46, 1992, ANNUAL REVIEWS INC., PALO ALTO, CA., US, pages 377 - 398, XP008025175, ISSN: 0066-4227
HORINOUCHI, S ET AL: "Autoregulatory factors of secondary metabolism and morphogenesis in actinomycetes", CRC CRITICAL REVIEWS IN BIOTECHNOLOGY, vol. 10, no. 3, 1990, CRC PRESS, BOCA RATON, FL, US, pages 191 - 204, XP008025176, ISSN: 0738-8551
Attorney, Agent or Firm:
Matulewicz, Emil Rudolf Antoni (Delft Office P.O. Box 1, MA Delft, NL)
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