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Title:
AUTOMATICALLY DETECTING CELLS HAVING NUCLEAR AND CYTOPLASMIC DENSITOMETRIC FEATURES ASSOCIATED WITH DISEASE BY OPTICAL IMAGING
Document Type and Number:
WIPO Patent Application WO2003061454
Kind Code:
A3
Abstract:
A system and method for rapidly detecting cells (1) of interest using multi-dimensional, highly quantitative, nuclear and cytoplasmic densitometric features (NDFs and CDFs) includes a flow optical tomography (FOT) instrument capable of generating various optical projection images (or shadowgrams) containing accurate density information from a cell, a computer (40) and software to analyze and reconstruct the projection images into a multi-dimensional data set, and automated feature collection and object classifiers. The system and method are particularly useful in the early detection of cancers such as lung cancer using a bronchial specimen from sputum or cheek scrapings and cervical/ovarian cancer using a cervical scraping, and the system can be used to detect rare cells in specimens including blood.

Inventors:
NELSON ALAN C
Application Number:
US0301761W
Publication Date:
September 04, 2003
Filing Date:
January 21, 2003
Export Citation:
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Assignee:
VISIONGATE, INC.
International Classes:
G01N21/64; C12Q1/04; G01N15/14; G01N21/00; G01N21/17; G01N21/78; G01N23/04; G01N33/48; G01N33/487; G01N33/50; G01N33/543; G01N33/554; G01N33/60; G03C3/00; G06F15/00; G06F19/00; G06K9/00; G06T1/00; G06T3/00; G06T7/00; G06T11/00; G01N21/05; A61B; (IPC1-7): G06K9/00; G01N33/487; G01N21/00; G06F19/00; G06F15/00; G01N21/64; G03C3/00
Foreign References:
US6251586B12001-06-26
US6165734A2000-12-26
US5987158A1999-11-16
US5281517A1994-01-25
US4175860A1979-11-27
US3999047A1976-12-21
Other References:
See also references of EP 1474033A2
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