Title:
AUXOTROPHIC, RECOMBINANT BCG STRAIN PASTEUR AND USE THEREOF FOR COMBATING HUMAN INFECTIONS CAUSED BY PARASITES
Document Type and Number:
WIPO Patent Application WO/2010/102363
Kind Code:
A8
Abstract:
The present invention relates to a recombinant BCG vaccine strain of Mycobacterium bovis that expresses the Sm14 antigen of Schistosoma mansoni (BCGr Pasteur ΔLeuD/pΔK410-hsp60*-Sm14). The vaccine strain according to the present invention is used for combating infection by parasites, particularly Schistosoma mansoni. The vaccine strain is a leucine-auxotrophic strain derived from the BCG substrain Pasteur, supplemented for leucine after genetic transformation with the construct pΔK410-hsp60*-SM14. The effectiveness of the BCGr Pasteur ΔLeuD/pΔK410-hsp60*-Sm14 strain for combating Schistosoma mansoni infection by expressing the recombinant Sm14 antigen in vivo is demonstrated in the present invention.
Inventors:
TENDLER MIRIAM (BR)
VILAR MONICA MAGNO (BR)
ARMOA GERALDO RODRIGUES GARCIA (BR)
MCINTOSH DOUGLAS (BR)
SIMPSON ANDREW J G (BR)
VILAR MONICA MAGNO (BR)
ARMOA GERALDO RODRIGUES GARCIA (BR)
MCINTOSH DOUGLAS (BR)
SIMPSON ANDREW J G (BR)
Application Number:
PCT/BR2010/000065
Publication Date:
October 06, 2011
Filing Date:
March 10, 2010
Export Citation:
Assignee:
FUNDACAO OSWALDO CRUZ (BR)
TENDLER MIRIAM (BR)
VILAR MONICA MAGNO (BR)
ARMOA GERALDO RODRIGUES GARCIA (BR)
MCINTOSH DOUGLAS (BR)
SIMPSON ANDREW J G (BR)
TENDLER MIRIAM (BR)
VILAR MONICA MAGNO (BR)
ARMOA GERALDO RODRIGUES GARCIA (BR)
MCINTOSH DOUGLAS (BR)
SIMPSON ANDREW J G (BR)
International Classes:
C12N15/76; A61P31/06; A61P33/10; A61P35/00
Attorney, Agent or Firm:
DE ALMEIDA, Katia Fernandes (Almeida & AssociadosRua Beneditinos 16, 11º andar,Cep: -05, Rio de Janeiro RJ, BR)
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