Title:
AXIAL-ASYMMETRIC N-(2-ACYLARYL)-2-[5, 7-DIHYDRO-6H-DIBENZO [C, E] AZEPINE-6-YL] ACETAMIDE COMPOUND AND CHIRALITY CONVERSION METHOD FOR Α-AMINO ACID USING SAME
Document Type and Number:
WIPO Patent Application WO/2014/098063
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a production method capable of high-yield/high-enantioselectively producing an optically active amino acid having few restrictions on the material that can be used as the substrate therefor; and a useful compound, as a chiral auxiliary agent; etc. The present invention provides an N-(2-acylaryl)-2-[5, 7-dihydro-6H-dibenzo [c, e] azepine-6-yl] acetamide compound indicated in formula (1), a salt thereof, or a metal complex indicated in formula (3).
Inventors:
MORIWAKI HIROKI (JP)
TAKEDA RYOSUKE (JP)
KAWAMURA AKIE (JP)
KAWASHIMA AKI (JP)
SOLOSHONOK VADIM A (US)
TAKEDA RYOSUKE (JP)
KAWAMURA AKIE (JP)
KAWASHIMA AKI (JP)
SOLOSHONOK VADIM A (US)
Application Number:
PCT/JP2013/083711
Publication Date:
June 26, 2014
Filing Date:
December 17, 2013
Export Citation:
Assignee:
HAMARI CHEMICALS LTD (JP)
International Classes:
C07D223/14; C07C227/32; C07C229/08; C07C229/36; C07B53/00; C07B61/00; C07F15/04
Domestic Patent References:
| WO2001081349A1 | 2001-11-01 |
Foreign References:
| JP2006213712A | 2006-08-17 | |||
| JP2009023989A | 2009-02-05 | |||
| JP2008115179A | 2008-05-22 | |||
| US7268252B2 | 2007-09-11 | |||
| US7847124B2 | 2010-12-07 |
Other References:
SOLOSHONOK V.A. ET AL: "APPLICATION OF MODULAR NUCLEOPHILIC GLYCINE EQUIVALENTS FOR TRULY PRACTICAL ASYMMETRIC SYNTHESIS OF BETA-SUBSTITUTED PYROGLUTAMIC ACIDS", TETRAHEDRON LETTERS, vol. 46, 2005, pages 1107 - 1110, XP004721783
ELLIS T.K. ET AL: "NEW GENERATION OF NUCLEOPHILIC GLYCINE EQUIVALENTS", TETRAHEDRON LETTERS, vol. 46, 2005, pages 941 - 944, XP004713855
SOLOSHONOK V.A. ET AL, J.AM.CHEM.SOC., vol. 131, no. 21, 2009, pages 7208 - 7209, XP055260246
PARK H. ET AL: "BIOINSPIRED CHEMICAL INVERSION OF L-AMINO ACIDS TO D-AMINO ACIDS", J.AM.CHEM.SOC., vol. 129, 2007, pages 1518 - 1519, XP002736711
MAIGROT N. ET AL, J.ORG.CHEM., vol. 50, no. 20, 1985, pages 3916 - 3918, XP055260264
DATABASE REGISTRY [online] 14 August 2011 (2011-08-14), XP055260789, retrieved from STN Database accession no. 1317399-32-8
DATABASE REGISTRY [online] 2 March 2009 (2009-03-02), XP055260792, retrieved from STN Database accession no. 1114360-57-4
DATABASE REGISTRY [online] 2 March 2009 (2009-03-02), XP055260795, retrieved from STN Database accession no. 1114360-59-6
DATABASE REGISTRY [online] 2 March 2009 (2009-03-02), XP055260797, retrieved from STN Database accession no. 1114360-61-0
DATABASE REGISTRY [online] 4 October 2000 (2000-10-04), XP055260804, retrieved from STN Database accession no. 292636-37-4
V. SOLOSHONOK ET AL., J. AM. CHEM. SOC., vol. 131, 2009, pages 7208
H. PARK ET AL., J. AM. CHEM. SOC., vol. 129, 2007, pages 1518
T. K. ELLIS ET AL., J. ORG. CHEM., vol. 71, 2006, pages 8572 - 8578
N. MAIGROT ET AL., J. ORG. CHEM., vol. 50, 1985, pages 3916 - 3918
See also references of EP 2942347A4
ELLIS T.K. ET AL: "NEW GENERATION OF NUCLEOPHILIC GLYCINE EQUIVALENTS", TETRAHEDRON LETTERS, vol. 46, 2005, pages 941 - 944, XP004713855
SOLOSHONOK V.A. ET AL, J.AM.CHEM.SOC., vol. 131, no. 21, 2009, pages 7208 - 7209, XP055260246
PARK H. ET AL: "BIOINSPIRED CHEMICAL INVERSION OF L-AMINO ACIDS TO D-AMINO ACIDS", J.AM.CHEM.SOC., vol. 129, 2007, pages 1518 - 1519, XP002736711
MAIGROT N. ET AL, J.ORG.CHEM., vol. 50, no. 20, 1985, pages 3916 - 3918, XP055260264
DATABASE REGISTRY [online] 14 August 2011 (2011-08-14), XP055260789, retrieved from STN Database accession no. 1317399-32-8
DATABASE REGISTRY [online] 2 March 2009 (2009-03-02), XP055260792, retrieved from STN Database accession no. 1114360-57-4
DATABASE REGISTRY [online] 2 March 2009 (2009-03-02), XP055260795, retrieved from STN Database accession no. 1114360-59-6
DATABASE REGISTRY [online] 2 March 2009 (2009-03-02), XP055260797, retrieved from STN Database accession no. 1114360-61-0
DATABASE REGISTRY [online] 4 October 2000 (2000-10-04), XP055260804, retrieved from STN Database accession no. 292636-37-4
V. SOLOSHONOK ET AL., J. AM. CHEM. SOC., vol. 131, 2009, pages 7208
H. PARK ET AL., J. AM. CHEM. SOC., vol. 129, 2007, pages 1518
T. K. ELLIS ET AL., J. ORG. CHEM., vol. 71, 2006, pages 8572 - 8578
N. MAIGROT ET AL., J. ORG. CHEM., vol. 50, 1985, pages 3916 - 3918
See also references of EP 2942347A4
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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