Title:
AZA HYDROXYLATED ETHYL AMINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2002094768
Kind Code:
A3
Abstract:
Disclosed are compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein RN, RC, R1, R2 and R20 are defined herein. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
Inventors:
SCHOSTAREZ HEINRICH (US)
CHRUSCIEL ROBERT ALLAN (US)
CENTKO REBECCA S (US)
CHRUSCIEL ROBERT ALLAN (US)
CENTKO REBECCA S (US)
Application Number:
PCT/US2002/016199
Publication Date:
March 20, 2003
Filing Date:
May 22, 2002
Export Citation:
Assignee:
ELAN PHARM INC (US)
UPJOHN CO (US)
SCHOSTAREZ HEINRICH (US)
CHRUSCIEL ROBERT ALLAN (US)
CENTKO REBECCA S (US)
UPJOHN CO (US)
SCHOSTAREZ HEINRICH (US)
CHRUSCIEL ROBERT ALLAN (US)
CENTKO REBECCA S (US)
International Classes:
A61K31/166; A61K31/18; A61K31/426; A61P25/00; C07D277/20; A61P25/16; A61P25/28; A61P43/00; C07C243/28; C07C243/32; C07C311/16; C07C311/49; C07D277/56; (IPC1-7): C07C243/28; A61K31/16; A61P25/28; C07D277/56
Domestic Patent References:
| WO2002002506A2 | 2002-01-10 | |||
| WO1999036404A1 | 1999-07-22 |
Foreign References:
| US6225345B1 | 2001-05-01 |
Download PDF: