Title:
AZA-PHENOTHIAZINE COMPOUND AND USE THEREOF IN PREPARING DRUG FOR TREATMENT OF ENDOMETRIAL CANCER
Document Type and Number:
WIPO Patent Application WO/2023/164940
Kind Code:
A1
Abstract:
Disclosed are an aza-phenothiazine derivative and use thereof in preparing a drug for the treatment of endometrial cancer. The structure of the derivative is represented by formula I, and the definitions of substituents are described in the description and claims. The aza-phenothiazine derivative of the present invention has an inhibitory effect on the proliferation, clonogenicity, and invasion ability of Ishikawa and KLE endometrial cancer cells, and can induce apoptosis. Therefore, the aza-phenothiazine derivative provided by the present invention is expected to be used for preparing a drug for the treatment and/or prevention of type I and type II endometrial cancer.
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Inventors:
WANG YUDONG (CN)
SUN XIAO (CN)
MAO FEI (CN)
WU HUIWEN (CN)
LIU XIAOHU (CN)
LI LIJUAN (CN)
LI JIAN (CN)
LI XIAOKANG (CN)
ZHU JIN (CN)
SUN XIAO (CN)
MAO FEI (CN)
WU HUIWEN (CN)
LIU XIAOHU (CN)
LI LIJUAN (CN)
LI JIAN (CN)
LI XIAOKANG (CN)
ZHU JIN (CN)
Application Number:
PCT/CN2022/079365
Publication Date:
September 07, 2023
Filing Date:
March 04, 2022
Export Citation:
Assignee:
INT PEACE MATERNITY AND CHILD HEALTH HOSPITAL (CN)
UNIV EAST CHINA SCIENCE & TECH (CN)
UNIV EAST CHINA SCIENCE & TECH (CN)
International Classes:
A61K31/5415; A61P35/00; C07D513/04
Foreign References:
| CN105073117A | 2015-11-18 | |||
| US20060258650A1 | 2006-11-16 | |||
| US6518423B1 | 2003-02-11 |
Other References:
KUSHWAHA K. ET AL.: "Novel aminoalkylated azaphenothiazines as potential inhibitors of T98G, H460 and SNU80 cancer cell lines in vitro", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 9, 15 March 2016 (2016-03-15), XP029500679, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.03.056
TSAKOVSKA I. M. ET AL.: "QSAR and 3D-QSAR of phenothiazine type multidrug resistance modulators in P388/ADR cells", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 13, 9 May 2003 (2003-05-09), XP085050399, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(03)00222-0
TSAKOVSKA I. M. ET AL.: "QSAR and 3D-QSAR of phenothiazine type multidrug resistance modulators in P388/ADR cells", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 13, 9 May 2003 (2003-05-09), XP085050399, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(03)00222-0
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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