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Title:
AZA-AND POLYAZA-NAPHTHALENYL KETONES USEFUL AS HIV INTEGRASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2002036734
Kind Code:
A3
Abstract:
Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

Inventors:
ZHUANG LINGHANG (US)
WAI JOHN S (US)
PAYNE LINDA S (US)
YOUNG STEVEN D (US)
FISHER THORSTEN E (US)
EMBREY MARK (US)
GUARE JAMES P (US)
Application Number:
PCT/US2001/042553
Publication Date:
July 11, 2002
Filing Date:
October 09, 2001
Export Citation:
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Assignee:
MERCK & CO INC (US)
ZHUANG LINGHANG (US)
WAI JOHN S (US)
PAYNE LINDA S (US)
YOUNG STEVEN D (US)
FISHER THORSTEN E (US)
EMBREY MARK (US)
GUARE JAMES P (US)
International Classes:
C07D215/26; A61K31/4375; A61K31/444; A61K31/4545; A61K31/47; A61K31/4709; A61K31/496; A61K31/513; A61K31/5377; A61P31/18; A61P43/00; C07D215/04; C07D401/06; C07D401/10; C07D471/04; C07D521/00; (IPC1-7): A61K31/47; A61K31/495; C07D215/26; C07D471/04
Foreign References:
US3113135A1963-12-03
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