Title:
AZABENZIMIDAZOLE COMPOUNDS AND PHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2019/216294
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide compounds having an M3 PAM action. Examples of the present invention include azabenzimidazole compounds represented, for example, by formula [I], and pharmacologically acceptable salts thereof. These compounds have M3 PAM activity. In addition, because these compounds have M3 PAM activity, these compounds are useful as agents for the prevention or treatment of dysuria and/or urine storage disorder in underactive bladder, hypotonic bladder, acontractile bladder, detrusor hypoactivity, and neurogenic bladder.
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Inventors:
OIKAWA KOUYA (JP)
HIRAI SHO (JP)
WAKITA KAZUHIKO (JP)
FUJIBAYASHI AKIKO (JP)
HIRAI SHO (JP)
WAKITA KAZUHIKO (JP)
FUJIBAYASHI AKIKO (JP)
Application Number:
PCT/JP2019/018201
Publication Date:
November 14, 2019
Filing Date:
May 07, 2019
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/4545; A61K31/46; A61K31/496; A61K31/497; A61K31/551; A61P3/10; A61P13/02; A61P13/10; A61P27/06; A61P43/00; C07D519/00
Foreign References:
| JP2016509048A | 2016-03-24 | |||
| JP2013545779A | 2013-12-26 | |||
| JP2013545776A | 2013-12-26 | |||
| JP2012031152A | 2012-02-16 | |||
| JP2011510044A | 2011-03-31 | |||
| JP2009510152A | 2009-03-12 |
Other References:
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BRITISH JOURNAL OF PHARMACOLOGY, vol. 148, no. 5, 2006, pages 565 - 578
ARABIAN JOURNAL OF UROLOGY, vol. 11, no. 4, 2013, pages 319 - 330
CLINICS IN COLON AND RECTAL SURGERY., vol. 25, 2012, pages 12 - 19
EXPERT OPINION ON PHARMACOTHERAPY, vol. 10, no. 16, 2009, pages 2663 - 2777
JOURNAL OF INFLAMMATION, vol. 14, 21 November 2017 (2017-11-21), pages 26
TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 38, no. 9, 2017, pages 837 - 847
NATURE, vol. 482, 2012, pages 552 - 556
CELL METABOLISM, vol. 3, 2006, pages 449 - 461
P.J. KOCIENSKI: "Protecting Groups", 2005, THIEME
"Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY SONS, INC.
"Organic Synthesis II Alcohol Amine", vol. 20, 1992, THE CHEMICAL SOCIETY OF JAPAN, article "Experimental Chemistry", pages: 280 - 282
G.S. ZWEIFELM.H. NANTZ: "Modern Organic Synthesis: An Introduction", 2009, KAGAKU-DOJIN PUBLISHING COMPANY, INC.
"Organic Synthesis VIII", vol. 26, THE CHEMICAL SOCIETY OF JAPAN, article "Experimental Chemistry", pages: 190 - 260
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 51, 1986, pages 4000 - 4005
TETRAHEDRON, vol. 59, 2003, pages 5417 - 5423
"GenBank", Database accession no. NM_000740.2
See also references of EP 3792260A4
BRITISH JOURNAL OF PHARMACOLOGY, vol. 148, no. 5, 2006, pages 565 - 578
ARABIAN JOURNAL OF UROLOGY, vol. 11, no. 4, 2013, pages 319 - 330
CLINICS IN COLON AND RECTAL SURGERY., vol. 25, 2012, pages 12 - 19
EXPERT OPINION ON PHARMACOTHERAPY, vol. 10, no. 16, 2009, pages 2663 - 2777
JOURNAL OF INFLAMMATION, vol. 14, 21 November 2017 (2017-11-21), pages 26
TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 38, no. 9, 2017, pages 837 - 847
NATURE, vol. 482, 2012, pages 552 - 556
CELL METABOLISM, vol. 3, 2006, pages 449 - 461
P.J. KOCIENSKI: "Protecting Groups", 2005, THIEME
"Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY SONS, INC.
"Organic Synthesis II Alcohol Amine", vol. 20, 1992, THE CHEMICAL SOCIETY OF JAPAN, article "Experimental Chemistry", pages: 280 - 282
G.S. ZWEIFELM.H. NANTZ: "Modern Organic Synthesis: An Introduction", 2009, KAGAKU-DOJIN PUBLISHING COMPANY, INC.
"Organic Synthesis VIII", vol. 26, THE CHEMICAL SOCIETY OF JAPAN, article "Experimental Chemistry", pages: 190 - 260
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 51, 1986, pages 4000 - 4005
TETRAHEDRON, vol. 59, 2003, pages 5417 - 5423
"GenBank", Database accession no. NM_000740.2
See also references of EP 3792260A4
Attorney, Agent or Firm:
NAKAMURA Ayatsugu (JP)
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