Title:
AZACITIDINE DISACCHARIDE IMPURITY, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/072005
Kind Code:
A1
Abstract:
The present invention relates to an azacitidine disaccharide impurity, a preparation method therefor and use thereof. A compound of formula III is obtained by reacting a compound represented by formula IV as a start raw material with a tetraacetyl ribose under the catalysis of a Lewis acid, and the compound of formula III is hydrolyzed to obtain a compound of formula II. The compound of formula II prepared can be used as a reference for the detection of related materials of azacitidine, and is used for quality control applications of azacitidine and related preparations thereof.
Inventors:
DENG HAICUN (CN)
GUO QI (CN)
JIANG BING (CN)
REN JINSHENG (CN)
ZHANG LIANDI (CN)
GUO QI (CN)
JIANG BING (CN)
REN JINSHENG (CN)
ZHANG LIANDI (CN)
Application Number:
PCT/CN2018/099074
Publication Date:
April 18, 2019
Filing Date:
August 07, 2018
Export Citation:
Assignee:
JIANGSU SIMCERE PHARM CO LTD (CN)
NANJING SIMCERE DONGYUAN PHARMACEUTICAL CO LTD (CN)
WUHU SIMCERE ZHONGREN PHARMACEUTICAL CO LTD (CN)
NANJING SIMCERE DONGYUAN PHARMACEUTICAL CO LTD (CN)
WUHU SIMCERE ZHONGREN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07H19/12; C07D251/06; C07H1/00
Domestic Patent References:
| WO2006099132A1 | 2006-09-21 |
Foreign References:
| CN104672289A | 2015-06-03 |
Other References:
NAEEM B. HANNA: "6-Methyl-5-Azacytidine-Synthesis, Conformational Pro- perties and Biological Activity. A Comparison of Molecular Conformation with 5-Azacytidine", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 16, 20 August 2006 (2006-08-20), ISSN: 0732-8311
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