Title:
AZAINDAZOLE MACROCYCLIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/040996
Kind Code:
A1
Abstract:
The present application relates to an azaindazole macrocyclic compound and the use thereof. The azainazole macrocyclic compound has a structure of formula I, and has the effect of inhibiting the activity of a plurality of protein kinases including, for example, HPK1, FLT3 and KDR.
Inventors:
DUAN GONGPING (CN)
ZHANG XINGMIN (CN)
LI MIN (CN)
ZHANG XINGMIN (CN)
LI MIN (CN)
Application Number:
PCT/CN2022/119179
Publication Date:
March 23, 2023
Filing Date:
September 16, 2022
Export Citation:
Assignee:
BROADENBIO CO LTD (CN)
International Classes:
C07D491/18; A61K31/439; A61K31/496; A61P35/00; A61P35/02; C07D491/22; C07D519/00; C07F9/6561
Domestic Patent References:
| WO2020006115A1 | 2020-01-02 | |||
| WO2018102366A1 | 2018-06-07 | |||
| WO2021168074A1 | 2021-08-26 | |||
| WO2018049191A1 | 2018-03-15 | |||
| WO2018049200A1 | 2018-03-15 | |||
| WO2018102366A1 | 2018-06-07 | |||
| WO2018183964A1 | 2018-10-04 | |||
| WO2019090198A1 | 2019-05-09 | |||
| WO2019206049A1 | 2019-10-31 | |||
| WO2019238067A1 | 2019-12-19 | |||
| WO2020092528A1 | 2020-05-07 |
Foreign References:
| US20190382402A1 | 2019-12-19 | |||
| CN112243439A | 2021-01-19 |
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KEIFER, F ET AL., THE EMBO JOURNAL, vol. 15, 1996, pages 7013 - 7025
DI BARTOLO, V ET AL., J. EXP. MED, vol. 204, 2007, pages 681 - 691
SHUI, J ET AL., NATURE IMMUNO, vol. 8, 2007, pages 84 - 91
LASSERRE, R ET AL., J. CELL BIOL., vol. 195, 2011, pages 839 - 853
ALZABIN, S ET AL., J. IMMUNOL., vol. 182, 2009, pages 6187 - 6194
ALZABIN, S ET AL., CANCER IMMUNOL. IMMUNOTHER, vol. 59, 2010, pages 419 - 429
HERNANDEZ, S ET AL., CELL REPORTS, vol. 25, 2018, pages 80 - 94
SAWASDIKOSOL, S ET AL., IMMUNOL. RES, vol. 54, 2012, pages 262 - 265
SAUER, K ET AL., J. BIOL. CHEM., vol. 276, 2001, pages 45207 - 45216
TSUJI, S ET AL., J. EXP. MED., vol. 194, 2001, pages 529 - 539
WANG, X ET AL., J. BIOL. CHEM., vol. 287, 2012, pages 34091 - 34100
KONIGSBERGER, S ET AL., PLOS ONE, vol. 5, 2010, pages e12468
ALZABIN, S ET AL., J. IMMUNOL, vol. 182, 2009, pages 6187 - 6194
LIU, J ET AL., PLOS ONE, vol. 14, 2019, pages e0212670
ZHANG, Q ET AL., J. AUTOIMMUN, vol. 37, 2011, pages 180 - 189
STOECKMAN, A. K ET AL., GENES IMMUN, vol. 7, 2006, pages 583 - 591
BALTIWALLA, F. M ET AL., MOL. MED., vol. 11, 2005, pages 21 - 29
CHEN-DEUTSCH, X ET AL., LEUK. RES, vol. 36, 2012, pages 884 - 888
CHEN-DEUTSCH, X ET AL., CELL CYCLE, vol. 11, 2012, pages 1364 - 1373
WANG. Y ET AL., MOL. MED. REP, vol. 5, 2012, pages 260 - 265
QIAN, Y ET AL., AM J. DERMATOPATHOL, vol. 33, 2011, pages 681 - 686
YANG, H.S ET AL., MOL. CELL BIOL, vol. 26, 2006, pages 1297 - 1306
GILLILAND, D.G ET AL., BLOOD, vol. 100, 2002, pages 1532 - 1542
STIREWALT, D.L ET AL., NAT. REV. CANCER, vol. 3, 2003, pages 650 - 665
NAKAO, M.S ET AL., LEUKEMIA, vol. 10, 1996, pages 1911 - 1918
KOTTARIDIS P.D., BLOOD, vol. 98, 2001, pages 1742 - 1759
BORTHEAKUR, G ET AL., HAEMATOLOGICA, vol. 96, January 2011 (2011-01-01), pages 62 - 68
Attorney, Agent or Firm:
BEIJING ZHENGHUAN INTELLECTUAL PROPERTY AGENCY (CN)
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