AZOLE COMPOUNDS - TAKEDA CHEMICAL INDUSTRIES LTD

Title:

AZOLE COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/2003/072554

Kind Code:

A1

Abstract:

Compounds represented by the general formula (I) or salts thereof which are useful in the prevention or treatment of diabetic neuropathy and so on: (I) wherein R¹ is hydrogen, halogeno, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, optionally substituted hydroxyl, optionally substituted mercapto, or optionally substituted amino; A is optionally substituted cycloamino or -NR²-W-D (wherein R² is hydrogen or alkyl; W is a free valency or a divalent acyclic hydrocarbon group; and D is an optionally substituted cyclic group, optionally substituted amino, or optionally substituted acyl); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is oxygen, sulfur, or optionally substituted nitrogen; and Y is a free valency and a divalent acyclic hydrocarbon group.

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Inventors:

SAKAI NOZOMU (JP)
MOMOSE YU (JP)
MURASE KATSUHITO (JP)
HAZAMA MASATOSHI (JP)

Application Number:

PCT/JP2003/002217

Publication Date:

September 04, 2003

Filing Date:

February 27, 2003

Export Citation:

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Assignee:

TAKEDA CHEMICAL INDUSTRIES LTD (JP)
SAKAI NOZOMU (JP)
MOMOSE YU (JP)
MURASE KATSUHITO (JP)
HAZAMA MASATOSHI (JP)

International Classes:

A61P3/10; A61P25/00; A61P25/24; A61P43/00; C07D263/32; C07D263/38; C07D263/46; C07D263/48; C07D277/28; C07D277/30; C07D277/40; C07D277/46; C07D413/04; C07D413/06; C07D413/12; C07D413/14; C07D417/04; C07D417/14; C07F9/653; C07F9/6539; (IPC1-7): C07D263/32; C07D263/46; C07D263/48; C07D277/28; C07D413/04; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D405/12; C07D417/04; C07D413/06; C07F9/6506; C07F9/653; C07F9/6539; C07F9/6558; C07F9/6561; A61K31/421; A61K31/422; A61K31/426; A61K31/427; A61K31/433; A61K31/4439; A61K31/454; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61K31/554; A61K31/675; A61K31/4545; A61K31/4709; A61P3/10; A61P25/00; A61P25/24; A61P43/00

Domestic Patent References:

WO1999002505A1	1999-01-21
WO2001077101A1	2001-10-18
WO2001010866A1	2001-02-15
WO2002020484A1	2002-03-14
WO1997036882A1	1997-10-09

Foreign References:

GB1425505A	1976-02-18
EP0987265A1	2000-03-22
EP0526877A2	1993-02-10
JPS4614458B1	1971-04-17
JPS5283747A	1977-07-12

Other References:

BENGTSSON STEFAN ET AL.: "Compounds related to clomethiazole VI. Synthesis of some reference compounds in connection with biotransformation studies", ACTA PHARM. SUEC., vol. 19, no. 1, 1982, pages 37 - 42, XP002968828
TADEUSZ JAKOBIEC ET AL.: "Synthesis of derivatives of 2-amino-4-P-chlorophenylthiazole-5-acetic acid", ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, vol. 26, no. 1-6, 1978, pages 935 - 941, XP002968829

Attorney, Agent or Firm:

Takahashi, Shuichi c/o Osaka Plant of TAKEDA CHEMICAL INDUSTRIES LTD. (17-85, Jusohonmachi 2-chome, Yodogawa-k, Osaka-shi Osaka, JP)

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