Title:
AZULENE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/045612
Kind Code:
A1
Abstract:
The present application belongs to the technical field of medicine, and discloses an azulene compound, and a preparation method therefor and the use thereof. The compound comprises two azulene compounds that are mutually isomers, and the chemical name thereof is 8-(1,2-dihydroxypropane-2-yl)-2-hydroxy-1,10-dimethyl-9-dihydroazulene-3,4-dione. The preparation method of the compound of the present invention is simple in terms of operation, and can obtain a pure compound by means of separating. Experiments show that the two compounds of the present invention have no significant effect on the growth of RAW 264.7 macrophages within 24 h, can significantly inhibit LPS-induced NO release of RAW264.7 cells and inhibit excessive secretion of IL-1β, IL-6 and TNF-α in cells, and have an obvious anti-inflammatory effect.
Inventors:
FENG YULIN (CN)
HE MINGZHEN (CN)
LI ZHIQIANG (CN)
LI ZHIFENG (CN)
OUYANG HUI (CN)
LI JUNMAO (CN)
YANG SHILIN (CN)
HE MINGZHEN (CN)
LI ZHIQIANG (CN)
LI ZHIFENG (CN)
OUYANG HUI (CN)
LI JUNMAO (CN)
YANG SHILIN (CN)
Application Number:
PCT/CN2022/111978
Publication Date:
March 30, 2023
Filing Date:
August 12, 2022
Export Citation:
Assignee:
JIANGXI BENCAO TIANGONG TECH CO LTD (CN)
UNIV JIANGXI TRADITIONAL CHINESE MEDICINE (CN)
UNIV JIANGXI TRADITIONAL CHINESE MEDICINE (CN)
International Classes:
C07C45/78; A61K31/122; A61P29/00; C07C45/79; C07C45/80; C07C49/755
Foreign References:
| CN113563172A | 2021-10-29 | |||
| JPH05178716A | 1993-07-20 | |||
| JPH0977694A | 1997-03-25 | |||
| CN107802674A | 2018-03-16 | |||
| CN113200811A | 2021-08-03 |
Other References:
MA, JIANGHAO ET.AL.: "Four New Sesquiterpenoids as Natural Nitric Oxide (NO) Inhibitors from the Rhizomes of Curcuma Phaeocaulis.", PHYTOCHEMISTRY LETTERS., no. 14, 10 November 2015 (2015-11-10), pages 221 - 225, XP029342333, ISSN: 1874-3900, DOI: 10.1016/j.phytol.2015.10.017
Attorney, Agent or Firm:
NANCHANG MAIEN INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
Download PDF:
Previous Patent: DEVICE CONTROL METHOD, APPARATUS AND SYSTEM, STORAGE MEDIUM, AND ELECTRONIC APPARATUS
Next Patent: HEAT DISSIPATION DEVICE AND SERVER
Next Patent: HEAT DISSIPATION DEVICE AND SERVER