Title:
B CELL ACTIVATION INHIBITOR, AND THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASES
Document Type and Number:
WIPO Patent Application WO/2016/084412
Kind Code:
A1
Abstract:
It is found that the activation of a B cell can be inhibited by TGF-beta3 produced by LAG3+ Treg. A B cell activation inhibitor comprising TGF-beta3 or a molecule having the function of TGF-beta3 and a therapeutic agent for autoimmune diseases are discovered.
Inventors:
FUJIO KEISHI (JP)
OKAMURA TOMOHISA (JP)
YAMAMOTO KAZUHIKO (JP)
MORITA KAORU (JP)
KOMAI TOSHIHIKO (JP)
BAN NOBUHIRO (JP)
MATSUURA TETSU (JP)
NONAKA TATSUYA (JP)
OKAMURA TOMOHISA (JP)
YAMAMOTO KAZUHIKO (JP)
MORITA KAORU (JP)
KOMAI TOSHIHIKO (JP)
BAN NOBUHIRO (JP)
MATSUURA TETSU (JP)
NONAKA TATSUYA (JP)
Application Number:
PCT/JP2015/065466
Publication Date:
June 02, 2016
Filing Date:
May 28, 2015
Export Citation:
Assignee:
UNIV TOKYO (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K38/00; A61K39/395; A61K47/42; A61K47/48; A61P5/16; A61P9/00; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P29/00; A61P31/22; A61P37/02; A61P37/06; A61P43/00; C07K14/475; C07K19/00
Domestic Patent References:
| WO2001081404A2 | 2001-11-01 | |||
| WO2008126940A1 | 2008-10-23 |
Foreign References:
| JP2014111603A | 2014-06-19 | |||
| JP2012211143A | 2012-11-01 |
Other References:
OKAMURA, T. ET AL.: "TGF-beta3-producing CD 4+ CD 25- LAG3+ regulatory T cells control humoral immunity", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 43, 18 November 2014 (2014-11-18), pages 174, XP009503209
FUJIO, K. ET AL.: "TGF-beta3-expressing CD 4+ CD 25- LAG3+ regulatory T cells control humoral immune responses", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 43, 18 November 2014 (2014-11-18), pages 20, XP009503271
IWASAKI, Y. ET AL.: "IL -27 induces regulatory T cells that suppress B cell responses", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 43, 18 November 2014 (2014-11-18), pages 190, XP009503221
KEISHI FUJIO ET AL.: "CD 4 Yosei CD 25 Insei LAG3 Yosei Seigyosei T Saibo no Mouse to Hito no Sohokosei no Kaiseki", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 36, no. 5, 2013, pages 310, XP055449008
SHIN'ICHIRO NAKACHI ET AL.: "Kansetsu Rheumatoid Kanja ni Okeru CD 4+ CD 25-LAG3+ Seigyosei T Saibo no Kaiseki", JAPAN COLLEGE OF RHEUMATOLOGY SOKAI - GAKUJUTSU SHUKAI, vol. 58 th, 24 March 2014 (2014-03-24), pages 439, XP009503219
KEISHI FUJIO ET AL.: "Zenshinsei Jiko Men'eki Shikkan o Yokusei suru Cytokine ni yoru B Saibo Seigyo", JAPAN COLLEGE OF RHEUMATOLOGY SOKAI GAKUJUTSU SHUKAI, vol. 59 th, 20 March 2015 (2015-03-20), pages 227, XP009503218
MARIKO INOUE ET AL.: "TGF-beta3 ni yoru B Saibo Seigyo Mechanism no Kaimei", JAPAN COLLEGE OF RHEUMATOLOGY SOKAI - GAKUJUTSU SHUKAI, vol. 59 th, 20 March 2015 (2015-03-20), pages 335, XP009503214
TOSHIHIKO KOMAI ET AL.: "Lupus-yo Byotai Seigyo ni Okeru TGF-beta3 no Yakuwari", JAPAN COLLEGE OF RHEUMATOLOGY SOKAI . GAKUJUTSU SHUKAI, vol. 59 th, 20 March 2015 (2015-03-20), pages 460, XP009503213
OKAMURA, T. ET AL.: "TGF-beta3-expressing CD 4+ CD 25-LAG3+ regulatory T cells control humoral immune responses", NAT. COMMUN., vol. 6, no. 6329, 19 February 2015 (2015-02-19), pages 1 - 14, XP055446048
SHAH, S. ET AL.: "Resting B cells expand a CD 4+ CD 25+Foxp3+ Treg population via TGF-beta3", EUR. J. IMMUNOL., vol. 38, no. 9, 2008, pages 2488 - 2498, XP055446051
KAORU MORITA ET AL.: "Tokushu Jiko Men'eki Ensho o Yokusei shiuru Shinki Saibo - Bunshi to sono Kino LAG3+T Saibo", KEYNOTE R.A, vol. 2, no. 3, 10 July 2014 (2014-07-10), pages 122 - 127, XP009503217
FUJIO, K. ET AL.: "TGF-beta3-expressing CD 4+ CD 25- LAG3+ regulatory T cells control humoral immune responses", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 43, 18 November 2014 (2014-11-18), pages 20, XP009503271
IWASAKI, Y. ET AL.: "IL -27 induces regulatory T cells that suppress B cell responses", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 43, 18 November 2014 (2014-11-18), pages 190, XP009503221
KEISHI FUJIO ET AL.: "CD 4 Yosei CD 25 Insei LAG3 Yosei Seigyosei T Saibo no Mouse to Hito no Sohokosei no Kaiseki", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 36, no. 5, 2013, pages 310, XP055449008
SHIN'ICHIRO NAKACHI ET AL.: "Kansetsu Rheumatoid Kanja ni Okeru CD 4+ CD 25-LAG3+ Seigyosei T Saibo no Kaiseki", JAPAN COLLEGE OF RHEUMATOLOGY SOKAI - GAKUJUTSU SHUKAI, vol. 58 th, 24 March 2014 (2014-03-24), pages 439, XP009503219
KEISHI FUJIO ET AL.: "Zenshinsei Jiko Men'eki Shikkan o Yokusei suru Cytokine ni yoru B Saibo Seigyo", JAPAN COLLEGE OF RHEUMATOLOGY SOKAI GAKUJUTSU SHUKAI, vol. 59 th, 20 March 2015 (2015-03-20), pages 227, XP009503218
MARIKO INOUE ET AL.: "TGF-beta3 ni yoru B Saibo Seigyo Mechanism no Kaimei", JAPAN COLLEGE OF RHEUMATOLOGY SOKAI - GAKUJUTSU SHUKAI, vol. 59 th, 20 March 2015 (2015-03-20), pages 335, XP009503214
TOSHIHIKO KOMAI ET AL.: "Lupus-yo Byotai Seigyo ni Okeru TGF-beta3 no Yakuwari", JAPAN COLLEGE OF RHEUMATOLOGY SOKAI . GAKUJUTSU SHUKAI, vol. 59 th, 20 March 2015 (2015-03-20), pages 460, XP009503213
OKAMURA, T. ET AL.: "TGF-beta3-expressing CD 4+ CD 25-LAG3+ regulatory T cells control humoral immune responses", NAT. COMMUN., vol. 6, no. 6329, 19 February 2015 (2015-02-19), pages 1 - 14, XP055446048
SHAH, S. ET AL.: "Resting B cells expand a CD 4+ CD 25+Foxp3+ Treg population via TGF-beta3", EUR. J. IMMUNOL., vol. 38, no. 9, 2008, pages 2488 - 2498, XP055446051
KAORU MORITA ET AL.: "Tokushu Jiko Men'eki Ensho o Yokusei shiuru Shinki Saibo - Bunshi to sono Kino LAG3+T Saibo", KEYNOTE R.A, vol. 2, no. 3, 10 July 2014 (2014-07-10), pages 122 - 127, XP009503217
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
Masao Haruna (JP)
Masao Haruna (JP)
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