Title:
B CELL SIGNATURE ASSOCIATED WITH TOLERANCE IN TRANSPLANT RECIPIENTS
Document Type and Number:
WIPO Patent Application WO/2010/138456
Kind Code:
A3
Abstract:
The present invention provides methods for predicting the development of tolerance to a transplant, such as a kidney, using molecular markers that have different expression patterns in tolerant transplant recipients, as compared to non-tolerant or healthy, non-recipient controls.
Inventors:
SEYFERT VICKI (US)
ASARE ADAM (US)
TURKA LAURENCE A (US)
NEWELL KENNETH (US)
ASARE ADAM (US)
TURKA LAURENCE A (US)
NEWELL KENNETH (US)
Application Number:
PCT/US2010/035966
Publication Date:
January 13, 2011
Filing Date:
May 24, 2010
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
UNIV PENNSYLVANIA (US)
UNIV EMORY (US)
SEYFERT VICKI (US)
ASARE ADAM (US)
TURKA LAURENCE A (US)
NEWELL KENNETH (US)
UNIV PENNSYLVANIA (US)
UNIV EMORY (US)
SEYFERT VICKI (US)
ASARE ADAM (US)
TURKA LAURENCE A (US)
NEWELL KENNETH (US)
International Classes:
C12Q1/68; G01N33/68
Domestic Patent References:
| WO2009064901A2 | 2009-05-22 |
Other References:
"GeneChip Human Genome U133 Set", INTERNET CITATION, 2001, XP002232760, Retrieved from the Internet [retrieved on 20030226]
BROUARD SOPHIE ET AL: "Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 25 SEP 2007 LNKD- PUBMED:17873064, vol. 104, no. 39, 25 September 2007 (2007-09-25), pages 15448 - 15453, XP002594926, ISSN: 0027-8424
SEYFERT-MARGOLIS VICKI ET AL: "Marking a path to transplant tolerance.", THE JOURNAL OF CLINICAL INVESTIGATION AUG 2008 LNKD- PUBMED:18654643, vol. 118, no. 8, August 2008 (2008-08-01), pages 2684 - 2686, XP007914218, ISSN: 0021-9738
DEMETRIS ANTHONY J ET AL: "Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective.", TRANSPLANT INTERNATIONAL : OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR ORGAN TRANSPLANTATION JAN 2009 LNKD- PUBMED:18980624, vol. 22, no. 1, January 2009 (2009-01-01), pages 120 - 141, XP007914232, ISSN: 0934-0874
GOLDMAN M ET AL: "Translating transplantation tolerance in the clinic: where are we, where do we go?", CLINICAL AND EXPERIMENTAL IMMUNOLOGY MAY 2009 LNKD- PUBMED:19250278, vol. 156, no. 2, 22 January 2009 (2009-01-22), pages 185 - 188, XP007914233, ISSN: 1365-2249
TURKA LAURENCE A ET AL: "Towards the identification of biomarkers of transplantation tolerance.", NATURE REVIEWS. IMMUNOLOGY JUL 2009 LNKD- PUBMED:19483711, vol. 9, no. 7, July 2009 (2009-07-01), pages 521 - 526, XP007914226, ISSN: 1474-1741
NEWELL KENNETH A ET AL: "Identification of a B cell signature associated with renal transplant tolerance in humans.", THE JOURNAL OF CLINICAL INVESTIGATION 1 JUN 2010 LNKD- DOI:10.1172/JCI39933 PUBMED:20501946, vol. 120, no. 6, 1 June 2010 (2010-06-01), pages 1836 - 1847, XP007914206, ISSN: 1558-8238
BROUARD SOPHIE ET AL: "Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 25 SEP 2007 LNKD- PUBMED:17873064, vol. 104, no. 39, 25 September 2007 (2007-09-25), pages 15448 - 15453, XP002594926, ISSN: 0027-8424
SEYFERT-MARGOLIS VICKI ET AL: "Marking a path to transplant tolerance.", THE JOURNAL OF CLINICAL INVESTIGATION AUG 2008 LNKD- PUBMED:18654643, vol. 118, no. 8, August 2008 (2008-08-01), pages 2684 - 2686, XP007914218, ISSN: 0021-9738
DEMETRIS ANTHONY J ET AL: "Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective.", TRANSPLANT INTERNATIONAL : OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR ORGAN TRANSPLANTATION JAN 2009 LNKD- PUBMED:18980624, vol. 22, no. 1, January 2009 (2009-01-01), pages 120 - 141, XP007914232, ISSN: 0934-0874
GOLDMAN M ET AL: "Translating transplantation tolerance in the clinic: where are we, where do we go?", CLINICAL AND EXPERIMENTAL IMMUNOLOGY MAY 2009 LNKD- PUBMED:19250278, vol. 156, no. 2, 22 January 2009 (2009-01-22), pages 185 - 188, XP007914233, ISSN: 1365-2249
TURKA LAURENCE A ET AL: "Towards the identification of biomarkers of transplantation tolerance.", NATURE REVIEWS. IMMUNOLOGY JUL 2009 LNKD- PUBMED:19483711, vol. 9, no. 7, July 2009 (2009-07-01), pages 521 - 526, XP007914226, ISSN: 1474-1741
NEWELL KENNETH A ET AL: "Identification of a B cell signature associated with renal transplant tolerance in humans.", THE JOURNAL OF CLINICAL INVESTIGATION 1 JUN 2010 LNKD- DOI:10.1172/JCI39933 PUBMED:20501946, vol. 120, no. 6, 1 June 2010 (2010-06-01), pages 1836 - 1847, XP007914206, ISSN: 1558-8238
Attorney, Agent or Firm:
JOHNS, Carol P. et al. (Two Embarcadero Center 8th Floo, San Francisco California, US)
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