Title:
B7-H3 ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/177393
Kind Code:
A1
Abstract:
The invention provides a B7-H3 antibody, an antigen-binding fragment thereof and a medical use thereof. Further, the present invention discloses a pharmaceutical composition comprising the B7-H3 antibody or antigen-binding fragment thereof, and the use thereof as a medicament. In particular, the invention discloses a use of a human B7-H3 human antibody or antigen-binding fragment thereof for the manufacture of a medicament for the treatment of a B7-H3-associated disease or condition.
Inventors:
GU JINMING (CN)
WANG XIAOHUA (CN)
YE XIN (CN)
YANG LIUQING (CN)
ZHANG TING (CN)
TAO WEIKANG (CN)
ZHANG LIANSHAN (CN)
WANG XIAOHUA (CN)
YE XIN (CN)
YANG LIUQING (CN)
ZHANG TING (CN)
TAO WEIKANG (CN)
ZHANG LIANSHAN (CN)
Application Number:
PCT/CN2018/081249
Publication Date:
October 04, 2018
Filing Date:
March 30, 2018
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/28; A61K39/00; C12Q1/68
Domestic Patent References:
| WO2010096734A2 | 2010-08-26 | |||
| WO2015181267A1 | 2015-12-03 | |||
| WO2008066691A2 | 2008-06-05 | |||
| WO2008100934A1 | 2008-08-21 | |||
| WO2010096734A2 | 2010-08-26 | |||
| WO2012147713A1 | 2012-11-01 | |||
| WO2015181267A1 | 2015-12-03 | |||
| WO2016044383A1 | 2016-03-24 |
Foreign References:
| CN102892426B | 2016-08-31 | |||
| CN101104639A | 2008-01-16 | |||
| CN103687945A | 2014-03-26 | |||
| CN106279416A | 2017-01-04 | |||
| US4683195A | 1987-07-28 |
Other References:
TISSUE ANTIGENS, vol. 70, no. 2, August 2007 (2007-08-01), pages 96 - 104
LUNG CANCER., vol. 66, no. 2, November 2009 (2009-11-01), pages 245 - 249
CLIN CANCER RES., vol. 14, no. 16, 15 August 2008 (2008-08-15), pages 5150 - 5157
CANCER RES., vol. 67, no. 16, 15 August 2007 (2007-08-15), pages 7893 - 7900
MOD PATHOL., vol. 23, no. 8, August 2010 (2010-08-01), pages 1104 - 1112
J NEUFOOOCOL, vol. 97, no. 3, 2010, pages 409 - 18
CURR OPIN BIOTECHNOL., vol. 13, no. 6, December 2002 (2002-12-01), pages 598 - 602
IMMUNOTECHNOLOGY, vol. 48, no. 13, 2013, pages 63 - 73
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT E.A. ET AL.: "Sequences of proteins of immunological interest", 1991, NIH
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG., vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES., vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL., 2001
PROTEIN ENGINEERING, vol. 7, 1994, pages 697
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
JOURNAL OF IMMUNOGLOBULINS, 2001
MULLIS ET AL.: "Molecular Biology of the Gene", vol. 51, 1987, THE BENJAMIN/CUMMINGS PUB. CO., pages: 263
"PCR TECHNOLOGY", 1989, STOCKTON PRESS
See also references of EP 3604337A4
LUNG CANCER., vol. 66, no. 2, November 2009 (2009-11-01), pages 245 - 249
CLIN CANCER RES., vol. 14, no. 16, 15 August 2008 (2008-08-15), pages 5150 - 5157
CANCER RES., vol. 67, no. 16, 15 August 2007 (2007-08-15), pages 7893 - 7900
MOD PATHOL., vol. 23, no. 8, August 2010 (2010-08-01), pages 1104 - 1112
J NEUFOOOCOL, vol. 97, no. 3, 2010, pages 409 - 18
CURR OPIN BIOTECHNOL., vol. 13, no. 6, December 2002 (2002-12-01), pages 598 - 602
IMMUNOTECHNOLOGY, vol. 48, no. 13, 2013, pages 63 - 73
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT E.A. ET AL.: "Sequences of proteins of immunological interest", 1991, NIH
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG., vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES., vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL., 2001
PROTEIN ENGINEERING, vol. 7, 1994, pages 697
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
JOURNAL OF IMMUNOGLOBULINS, 2001
MULLIS ET AL.: "Molecular Biology of the Gene", vol. 51, 1987, THE BENJAMIN/CUMMINGS PUB. CO., pages: 263
"PCR TECHNOLOGY", 1989, STOCKTON PRESS
See also references of EP 3604337A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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