B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION

WIPO Patent Application WO2002099119

A3

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL2 and splice variants thereof. The present invention further provides isolated B7-related polypeptides that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for diagnostic applications and the immunomodulation of a human or animal subject.

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MIKESELL GLEN E (US)
SHEN HENRY (US)

PCT/US2002/018049

February 03, 2005

June 06, 2002

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BRISTOL MYERS SQUIBB CO (US)
MIKESELL GLEN E (US)
SHEN HENRY (US)

C07K14/705; C07K16/28; C12N1/21; C12N15/62; A61K38/00; (IPC1-7): C07H21/04; C12N15/00; C12N15/09; C12N15/63; C07K14/705; C07K16/28; C07K16/46

WO2001018021A1

2001-03-15

CHAPOVAL ET AL.: "B7-H3: a costimulatory molecule or for T cell activation and IFN-y production", NATURE IMMUNOL., vol. 2, no. 3, March 2001 (2001-03-01), pages 269 - 274, XP002958730

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