Title:
BETA-LACTAM INHIBITORS OF CoA-IT
Document Type and Number:
WIPO Patent Application WO1998050032
Kind Code:
A9
Abstract:
This invention relates to a novel method for treating disease or disorders mediated by the lipid inflammatory mediators, arachidonic acid, its metabolites and/or platelet activating factor (PAF), which method comprising administering to a mammal in need thereof an effective Coenzyme A independent transacylase (CoA-IT) inhibiting amount of a compound of formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of formula (I).
Inventors:
BONDINELL WILLIAM E (US)
WINKLER JAMES DAVID (US)
WINKLER JAMES DAVID (US)
Application Number:
PCT/US1998/009483
Publication Date:
March 25, 1999
Filing Date:
May 08, 1998
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORP (US)
BONDINELL WILLIAM E (US)
WINKLER JAMES DAVID (US)
BONDINELL WILLIAM E (US)
WINKLER JAMES DAVID (US)
International Classes:
A61K31/397; A61K31/4436; A61P1/00; A61P1/04; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P37/08; A61P43/00; C07D205/085; C07D205/095; C07D405/12; C07D409/14; (IPC1-7): A61K31/395
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