Title:
BACTERIA ENGINEERED TO TREAT DISEASES THAT BENEFIT FROM REDUCED GUT INFLAMMATION AND/OR TIGHTENED GUT MUCOSAL BARRIER
Document Type and Number:
WIPO Patent Application WO/2017/136792
Kind Code:
A3
Abstract:
Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
Inventors:
MILLER PAUL F (US)
ISABELLA VINCENT M (US)
KOTULA JONATHAN W (US)
FALB DEAN (US)
FISHER ADAM B (US)
MILLET YVES (US)
LI NING (US)
ISABELLA VINCENT M (US)
KOTULA JONATHAN W (US)
FALB DEAN (US)
FISHER ADAM B (US)
MILLET YVES (US)
LI NING (US)
Application Number:
PCT/US2017/016603
Publication Date:
September 08, 2017
Filing Date:
February 03, 2017
Export Citation:
Assignee:
SYNLOGIC INC (US)
International Classes:
C12N15/70; A61K35/74; C12N15/74; C12P7/52
Domestic Patent References:
| WO2016141108A1 | 2016-09-09 | |||
| WO2008143704A2 | 2008-11-27 |
Foreign References:
| US20160206666A1 | 2016-07-21 |
Other References:
E.-H. ABOULNAGA ET AL: "Effect of an Oxygen-Tolerant Bifurcating Butyryl Coenzyme A Dehydrogenase/Electron-Transferring Flavoprotein Complex from Clostridium difficile on Butyrate Production in Escherichia coli", JOURNAL OF BACTERIOLOGY, vol. 195, no. 16, 14 June 2013 (2013-06-14), US, pages 3704 - 3713, XP055373221, ISSN: 0021-9193, DOI: 10.1128/JB.00321-13
SAINI M ET AL: "Metabolic engineering of Escherichia coli for production of butyric acid", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 20140514 AMERICAN CHEMICAL SOCIETY USA,, vol. 62, no. 19, 14 May 2014 (2014-05-14), pages 4342 - 4348, XP002769212, DOI: 10.1021/JF500355P
DAVID RÍOS-COVIÁN ET AL: "Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health", FRONTIERS IN MICROBIOLOGY, vol. 7, 16 February 2016 (2016-02-16), XP055372290, DOI: 10.3389/fmicb.2016.00185
VANDENBROUCKE ET AL: "Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice", GASTROENTEROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 127, no. 2, 1 August 2004 (2004-08-01), pages 502 - 513, XP005314157, ISSN: 0016-5085, DOI: 10.1053/J.GASTRO.2004.05.020
HAMADY ZAED Z R ET AL: "Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus", GUT, BRITISH MEDICAL ASSOCIATION, LONDON, UK, vol. 59, no. 4, 1 April 2010 (2010-04-01), pages 461 - 469, XP009174834, ISSN: 0017-5749, DOI: 10.1136/GUT.2008.176131
ERIC J. ARCHER ET AL: "Engineered E. coli That Detect and Respond to Gut Inflammation through Nitric Oxide Sensing", ACS SYNTHETIC BIOLOGY, vol. 1, no. 10, 19 October 2012 (2012-10-19), USA, pages 451 - 457, XP055260073, ISSN: 2161-5063, DOI: 10.1021/sb3000595
ANDERSON J C ET AL: "Environmentally Controlled Invasion of Cancer Cells by Engineered Bacteria", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 355, no. 4, 27 January 2006 (2006-01-27), pages 619 - 627, XP024950592, ISSN: 0022-2836, [retrieved on 20060127], DOI: 10.1016/J.JMB.2005.10.076
SAINI M ET AL: "Metabolic engineering of Escherichia coli for production of butyric acid", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 20140514 AMERICAN CHEMICAL SOCIETY USA,, vol. 62, no. 19, 14 May 2014 (2014-05-14), pages 4342 - 4348, XP002769212, DOI: 10.1021/JF500355P
DAVID RÍOS-COVIÁN ET AL: "Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health", FRONTIERS IN MICROBIOLOGY, vol. 7, 16 February 2016 (2016-02-16), XP055372290, DOI: 10.3389/fmicb.2016.00185
VANDENBROUCKE ET AL: "Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice", GASTROENTEROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 127, no. 2, 1 August 2004 (2004-08-01), pages 502 - 513, XP005314157, ISSN: 0016-5085, DOI: 10.1053/J.GASTRO.2004.05.020
HAMADY ZAED Z R ET AL: "Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus", GUT, BRITISH MEDICAL ASSOCIATION, LONDON, UK, vol. 59, no. 4, 1 April 2010 (2010-04-01), pages 461 - 469, XP009174834, ISSN: 0017-5749, DOI: 10.1136/GUT.2008.176131
ERIC J. ARCHER ET AL: "Engineered E. coli That Detect and Respond to Gut Inflammation through Nitric Oxide Sensing", ACS SYNTHETIC BIOLOGY, vol. 1, no. 10, 19 October 2012 (2012-10-19), USA, pages 451 - 457, XP055260073, ISSN: 2161-5063, DOI: 10.1021/sb3000595
ANDERSON J C ET AL: "Environmentally Controlled Invasion of Cancer Cells by Engineered Bacteria", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 355, no. 4, 27 January 2006 (2006-01-27), pages 619 - 627, XP024950592, ISSN: 0022-2836, [retrieved on 20060127], DOI: 10.1016/J.JMB.2005.10.076
Attorney, Agent or Firm:
HANLEY, Elizabeth, A. et al. (US)
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