BACTERIAL EXPRESSION SYSTEMS

WIPO Patent Application WO2002038739

A1

An inducible expression system is provided that includes an inducible ansB promoter co-dependently regulatable by cyclic AMP and anaerobiosis. The expression system is particularlysuited to chromosomal expression of immunogenic proteins in attenuated bacterial vaccines.Protein expression from an E. coli-derived ansB promoter is particularly effective in aSalmonella host bacterium.

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TERRY TAMSIN DEBORAH (AU)
JENNINGS MICHAEL PAUL (AU)

PCT/AU2001/001455

May 16, 2002

November 09, 2001

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UNIV QUEENSLAND (AU)
TERRY TAMSIN DEBORAH (AU)
JENNINGS MICHAEL PAUL (AU)

C12N1/11; C12N9/82; C12N15/68; C12N15/70; C12N15/74; (IPC1-7): C12N1/11; C12N15/63; C12N15/64; C12N15/65; A61K39/00

SCOTT S. ET AL: "Transcriptional co-activation at the ansB promoters:involvement of the activating regions of CRP and FNR when bound in tandem.", MOL. MICROBIOL., vol. 18, no. 3, November 1995 (1995-11-01), pages 521 - 531, XP002976842
JENNINGS M.P. ET AL: "Regulation of the ansB gene of Salmonella enterica.", MOL. MICROBIOL., vol. 9, no. 1, July 1993 (1993-07-01), pages 165 - 172, XP002977901
JENNINGS M.P. ET AL: "Co-dependent positive regulation of the ansB promoter of Escherichia coli by CRP and the FNR protein: a molecular analysis.", MOL. MICROBIOL., vol. 9, no. 1, July 1993 (1993-07-01), pages 155 - 164, XP002976900

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