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Title:
BACTERIAL POLYPEPTIDES INVOLVED IN VIABILITY
Document Type and Number:
WIPO Patent Application WO2003102190
Kind Code:
A3
Abstract:
The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.

Inventors:
EDWARDS ALED (CA)
DHARAMSI AKIL (CA)
VEDADI MASOUD (CA)
VALLEE FRANCOIS (CA)
AWREY DONALD (CA)
BEATTIE BRYAN (CA)
RICHARDS DAWN (CA)
DOMAGALA MEGAN (CA)
MANSOURY KAMRAN (CA)
VIRAG CRISTINA (CA)
BUZADZIJA KRISTINA (CA)
MCDONALD MERRY-LYNN (CA)
HOUSTON SIMON (CA)
ARROWSMITH CHERYL (CA)
OUYANG HUI (CA)
NETHERY KATHLEEN (CA)
NG IVY (CA)
KANAGARAJAH DHUSHY (CA)
Application Number:
CA0300786W
Publication Date:
May 21, 2004
Filing Date:
June 02, 2003
Export Citation:
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Assignee:
AFFINIUM PHARMACEUTICALS, INC.
EDWARDS, ALED
DHARAMSI, AKIL
VEDADI, MASOUD
VALLEE, FRANCOIS
AWREY, DONALD
BEATTIE, BRYAN
RICHARDS, DAWN
DOMAGALA, MEGAN
MANSOURY, KAMRAN
VIRAG, CRISTINA
BUZADZIJA, KRISTINA
MCDONALD, MERRY-LYNN
HOUSTON, SIMON
ARROWSMITH, CHERYL
OUYANG, HUI
NETHERY, KATHLEEN
NG, IVY
KANAGARAJAH, DHUSHY
International Classes:
C07K1/36; C07K14/205; C07K14/21; C07K14/245; C07K14/31; C07K14/315; C12N1/06; C12N9/00; C12N9/02; C12N9/04; C12N9/06; C12N9/10; C12N9/12; C12N9/48; C12N9/78; C12N9/88; C12N9/90; C12N15/31; (IPC1-7): C12N15/31; C07K14/195; C12N15/62; G01N33/50
Foreign References:
EP1094070A22001-04-25
Other References:
DATABASE EMBL, HEIDELBERG, FRG [online] 13 February 2002 (2002-02-13), "Staphylococcus aureus DNA for cellular proliferation protein #50", XP002265525, Database accession no. AAS51633
DATABASE EMBL, HEIDELBERG, FRG [online] 14 February 2002 (2002-02-14), "Staphylococcus aureus cellular proliferation protein #50", XP002265526, Database accession no. AAU33774
DATABASE EMBL, HEIDELBERG, FRG [online] 13 February 2002 (2002-02-13), "Staphylococcus aureus cellular proliferation inhibitory sequence #370", XP002265527, Database accession no. AAS49146
DATABASE EMBL, HEIDELBERG, FRG [online] 13 February 2002 (2002-02-13), "Staphylococcus aureus cellular proliferation inhibitory sequence #1034", XP002265528, Database accession no. AAS49810
DATABASE EMBL, HEIDELBERG, FRG [online] 20 February 2003 (2003-02-20), XP002265529, Database accession no. AX619330
DATABASE EMBL, HEIDELBERG, FRG [online] 20 February 2003 (2003-02-20), XP002265530, Database accession no. AX619331
DATABASE EMBL, HEIDELBERG, FRG [online] 1 November 1997 (1997-11-01), GREEN, C.J. & VOLD, B.S.: "Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS)", XP002265531, Database accession no. Q53638
BROWN, M.J.B. ET AL.: "Rational Design of Femtomolar Inhibitors of Isoleucyl tRNA Synthetase from a Binding Model for Pseudomonic Acid-A", BIOCHEMISTRY, vol. 39, no. 20, 23 May 2000 (2000-05-23), pages 6003 - 6011, XP002249801
BAGBY, S. ET AL.: "Optimization of Protein Solubility and Stability for Protein Nuclear Magnetic Resonance", METHODS IN ENZYMOLOGY, vol. 339, 2001, pages 20 - 41, XP001152932
KRAFT, P. ET AL.: "Infrared, Surface-Assisted Laser Desorption Ionization Mass Spectrometry on Frozen Aqueous Solutions of Proteins and Peptides Using Suspensions of Organic Solids", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 9, no. 9, September 1998 (1998-09-01), pages 912 - 924, XP004149186
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