Title:
BACTERIUM CONSTITUTIVELY PRODUCING MONOPHOSPHORYL LIPID A AND METHOD OF PRODUCING MONOPHOSPHORYL LIPID A BY USING BACTERIUM
Document Type and Number:
WIPO Patent Application WO/2019/009593
Kind Code:
A3
Abstract:
A bacterium that constitutively produces monophosphoryl lipid A (MLA) and a method of producing MLA by using the bacterium may simply produce MLA and a derivative thereof without acid hydrolysis, reduce a probability of natural mutation, and increase yields of MLA and a derivative thereof by constitutive expression of the MLA and derivative thereof.
Inventors:
CHUNG HAK SUK (KR)
JI YU HYUN (KR)
AN JIN SU (KR)
KWON ICK CHAN (KR)
YANG EUN GYEONG (KR)
JI YU HYUN (KR)
AN JIN SU (KR)
KWON ICK CHAN (KR)
YANG EUN GYEONG (KR)
Application Number:
PCT/KR2018/007526
Publication Date:
April 11, 2019
Filing Date:
July 03, 2018
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
C12N15/74; C12N9/14; C12N9/16; C12P19/04
Foreign References:
| KR20160028870A | 2016-03-14 | |||
| US20130230555A1 | 2013-09-05 |
Other References:
CHEN, JIUZHOU ET AL.: "Construction of an Escherichia coli mutant producing monophosphoryl lipid A", BIOTECHNOLOGY LETTERS, vol. 33, no. 5, 2011, pages 1013 - 1019, XP055590087
HAN, YANING ET AL.: "Construction of monophosphoryl lipid A producing Escherichia coli mutants and comparison of immuno-stimulatory activities of their lipopolysaccharides", MARINE DRUGS, vol. 11, no. 2, 2013, pages 363 - 376, XP055397358, DOI: doi:10.3390/md11020363
EL GHACHI, MERIEM ET AL.: "Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 19, 2005, pages 18689 - 18695, XP055062543, DOI: doi:10.1074/jbc.M412277200
HAN, YANING ET AL.: "Construction of monophosphoryl lipid A producing Escherichia coli mutants and comparison of immuno-stimulatory activities of their lipopolysaccharides", MARINE DRUGS, vol. 11, no. 2, 2013, pages 363 - 376, XP055397358, DOI: doi:10.3390/md11020363
EL GHACHI, MERIEM ET AL.: "Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 19, 2005, pages 18689 - 18695, XP055062543, DOI: doi:10.1074/jbc.M412277200
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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