Title:
BACTEROIDES FRAGILIS FOR RELIEVING ENDOTOXIN INFECTION, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/205505
Kind Code:
A1
Abstract:
Provided are bacteroides fragilis CCFM1020 for relieving endotoxin infection, and an application thereof. The bacteroides fragilis has low immunogenicity, and can reduce the content of proinflammatory factors in the blood of a host infected with endotoxin, increase the concentration of anti-inflammatory factors, increase the number of Foxp3+ regulatory T cells, and stabilize the composition of intestinal flora. Also provided is a pharmaceutical composition comprising the bacteroides fragilis CCFM1020 for relieving endotoxin infection.
Inventors:
ZHAI QIXIAO (CN)
CHEN WEI (CN)
TAN HUIZI (CN)
LU WENWEI (CN)
TIAN FENGWEI (CN)
ZHAO JIANXIN (CN)
ZHANG HAO (CN)
CHEN WEI (CN)
TAN HUIZI (CN)
LU WENWEI (CN)
TIAN FENGWEI (CN)
ZHAO JIANXIN (CN)
ZHANG HAO (CN)
Application Number:
PCT/CN2018/110059
Publication Date:
October 31, 2019
Filing Date:
October 12, 2018
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
C12N1/20; A61K35/741; A61P1/00; A61P39/02; C12N1/04; C12R1/01
Foreign References:
| CN108611295A | 2018-10-02 | |||
| CN106399141A | 2017-02-15 |
Other References:
ELAINE Y. HSIAO: "The microbiota modulates gut physiology and behavioral abnormalities associated with autism", CELL ., 19 December 2013 (2013-12-19), XP055648250, ISSN: 0092-8674
FENG SHUZHEN, ET AL.: "The Research Progress of Bacteroides Fragilis", MICROBIOLOGY, vol. 42, no. 7, 20 July 2015 (2015-07-20), XP055361914, ISSN: 0253-2654, DOI: 10.13344/j.microbiol.china.140778
ZHANG JIJIE, ET AL.: "Isolation and Identification of Non-toxic Bacteroides Fragilis", NINGXIA MEDICAL JOURNAL, vol. 13, no. 4, 30 April 1991 (1991-04-30), ISSN: 1001-5949
ZHANG JIJIE, ET AL.: "Clinical Application of Bacteroides Fragilis (BF839) Fluid", CHINESE JOURNAL OF BIOLOGICALS, vol. 8, no. 2, 28 February 1995 (1995-02-28), XP055582450, ISSN: 1004-5503
FENG SHUZHEN, ET AL.: "The Research Progress of Bacteroides Fragilis", MICROBIOLOGY, vol. 42, no. 7, 20 July 2015 (2015-07-20), XP055361914, ISSN: 0253-2654, DOI: 10.13344/j.microbiol.china.140778
ZHANG JIJIE, ET AL.: "Isolation and Identification of Non-toxic Bacteroides Fragilis", NINGXIA MEDICAL JOURNAL, vol. 13, no. 4, 30 April 1991 (1991-04-30), ISSN: 1001-5949
ZHANG JIJIE, ET AL.: "Clinical Application of Bacteroides Fragilis (BF839) Fluid", CHINESE JOURNAL OF BIOLOGICALS, vol. 8, no. 2, 28 February 1995 (1995-02-28), XP055582450, ISSN: 1004-5503
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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