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Title:
BAG3 AS A TARGET FOR THERAPY OF HEART FAILURE
Document Type and Number:
WIPO Patent Application WO/2015/117010
Kind Code:
A3
Abstract:
Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

Inventors:
FELDMAN, Arthur, M. (136 Knightsbridge, Wynnewood, PA, 19096, US)
TILLEY, Douglas, G. (846 Penn St, Bryn Mawr, PA, 19010, US)
ZHU, Weizhong (33 Winterberry Court, Cockeysville, MD, 21030, US)
KHALILI, Kamel (190 Presidential Boulevard, #718Bala Cynwyd, PA, 19004, US)
KOCH, Walter, J. (13 Kathryn Lane, Broomall, PA, 19008, US)
Application Number:
US2015/013926
Publication Date:
September 24, 2015
Filing Date:
January 30, 2015
Export Citation:
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Assignee:
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (1938 Liacouras Walk, Room 211Philadelphia, PA, 19122-6029, US)
International Classes:
A61K48/00; A61P9/00; A61P21/00
Domestic Patent References:
WO2010138263A22010-12-02
Foreign References:
EP1323733A12003-07-02
Other References:
BEGAY, R ET AL.: "Exome sequencing identifies bag3 gene mutation in dilated cardiomyopathy'.", CIRCULATION, vol. 128, no. Issue.22, 2013
ODGEREL, Z. ET AL.: "Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation'.", NEUROMUSCULAR DISORDERS, vol. 20, no. 7, 2010, pages 438 - 442, XP027104039, ISSN: 0960-8966
HOMMA, S. ET AL.: "BAG3 deficiency results in fulminant myopathy and early lethality'.", THE AMERICAN JOURNAL OF PATHOLOGY, vol. 169, no. 3, 2006, pages 761 - 773, XP055329887
See also references of EP 3099333A4
Attorney, Agent or Firm:
TEMELES, Gretchen, L. et al. (Duane Morris LLP, 30 South 17th StreetPhiladelphia, PA, 19103, US)
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