Title:
BAICALEIN DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/040733
Kind Code:
A1
Abstract:
Disclosed in the present invention are a class of baicalein derivatives, and a preparation method therefor and the uses thereof. The structure of the baicalein derivative of the present invention is as represented by the following general formula (I). According to pharmacological experiment verification, the baicalein derivative of the present invention exhibits an inhibitory activity against novel coronavirus, and can be used as an anti-novel coronavirus drug or a potential drug for treating related diseases caused by the novel coronavirus.
Inventors:
SHEN JINGSHAN (CN)
XU YECHUN (CN)
XIAO GENGFU (CN)
JIANG XIANGRUI (CN)
SU HAIXIA (CN)
XIE HANG (CN)
SHANG WEIJUAN (CN)
ZHANG SUQING (CN)
WANG ZHEN (CN)
ZHANG LEIKE (CN)
JIANG HUALIANG (CN)
XU YECHUN (CN)
XIAO GENGFU (CN)
JIANG XIANGRUI (CN)
SU HAIXIA (CN)
XIE HANG (CN)
SHANG WEIJUAN (CN)
ZHANG SUQING (CN)
WANG ZHEN (CN)
ZHANG LEIKE (CN)
JIANG HUALIANG (CN)
Application Number:
PCT/CN2022/117692
Publication Date:
March 23, 2023
Filing Date:
September 08, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
WUHAN INST VIROLOGY CAS (CN)
WUHAN INST VIROLOGY CAS (CN)
International Classes:
C07D311/32; A61K31/352; A61K31/353; A61K31/7048; A61P31/12; A61P31/14; C07D311/30; C07H17/07
Domestic Patent References:
| WO2016153432A1 | 2016-09-29 | |||
| WO2009026166A2 | 2009-02-26 | |||
| WO2001003681A2 | 2001-01-18 |
Foreign References:
| CN110950828A | 2020-04-03 | |||
| CN112110889A | 2020-12-22 | |||
| US20150329515A1 | 2015-11-19 | |||
| US20140194500A1 | 2014-07-10 | |||
| CN1594308A | 2005-03-16 | |||
| CN1901921A | 2007-01-24 |
Other References:
GAO, HONG ET AL.: "Structure-activity Relationships for α-Glucosidase Inhibition of Baicalein, 5, 6, 7-Trihydroxyflavone: the Effect of A-Ring Substitution", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 68, no. 2, 1 January 2004 (2004-01-01), XP009099477, ISSN: 0916-8451, DOI: 10.1271/bbb.68.369
LIU XIN-YU; LV XIA; WANG PING; AI CHUN-ZHI; ZHOU QI-HANG; FINEL MOSHE; FAN BIN; CAO YUN-FENG; TANG HUI; GE GUANG-BO: "Inhibition of UGT1A1 by natural and synthetic flavonoids", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, ELSEVIER BV, NL, vol. 126, 1 January 1900 (1900-01-01), NL , pages 653 - 661, XP085602143, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2018.12.171
LIU XIN-YU; LV XIA; WANG PING; AI CHUN-ZHI; ZHOU QI-HANG; FINEL MOSHE; FAN BIN; CAO YUN-FENG; TANG HUI; GE GUANG-BO: "Inhibition of UGT1A1 by natural and synthetic flavonoids", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, ELSEVIER BV, NL, vol. 126, 1 January 1900 (1900-01-01), NL , pages 653 - 661, XP085602143, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2018.12.171
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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