Title:
BAICALIN MAGNESIUM, PREPARATION METHOD THEREOF AND APPLICATION OF SAME
Document Type and Number:
WIPO Patent Application WO/2017/133465
Kind Code:
A1
Abstract:
The present invention relates to a baicalin magnesium and further relates to a preparation method and extraction method of the baicalin magnesium. The preparation method comprises the steps of preparing a suspension of a baicalin, preparing a suspension containing a magnesium ion, reacting, and drying. The extraction method comprises the steps of pre-processing with a macroporous adsorption resin, extracting, adsorbing and eluting, concentrating and drying, and purifying. The baicalin magnesium preparation restores the baicalin to an original form found in the Scutellaria baicalensis plant, and can be used as a substitute for the baicalin in pharmaceutical applications. Compared with the baicalin, the baicalin magnesium has greatly increased solubility, faster oral absorption rate and higher bioavailability. The baicalin magnesium can also be easily formulated as a water-soluble agent or powder agent for injection. Pharmacological experiments showed that the baicalin magnesium is more pharmacologically active than baicalin.
Inventors:
LIU CUIZHE (CN)
WANG ZHIXUAN (CN)
MIAO CEYU (CN)
LIU LIYAN (CN)
XUE HEFEI (CN)
LIU XIGANG (CN)
DU WENSHAN (CN)
LIU YIXIN (CN)
ZHANG LIN (CN)
MAO XIAOXIA (CN)
LIU JINJUN (CN)
ZHAO GUIQIN (CN)
WANG ZHIXUAN (CN)
MIAO CEYU (CN)
LIU LIYAN (CN)
XUE HEFEI (CN)
LIU XIGANG (CN)
DU WENSHAN (CN)
LIU YIXIN (CN)
ZHANG LIN (CN)
MAO XIAOXIA (CN)
LIU JINJUN (CN)
ZHAO GUIQIN (CN)
Application Number:
PCT/CN2017/071616
Publication Date:
August 10, 2017
Filing Date:
January 19, 2017
Export Citation:
Assignee:
CHENGDE MEDICAL COLLEGE (CN)
International Classes:
C07H23/00; A61K31/7048; A61P1/16; A61P3/10; A61P9/10; A61P29/00; A61P35/00; C07H1/00
Foreign References:
| CN105061538A | 2015-11-18 |
Other References:
WANG, NING ET AL.: "Interaction between scutellaria baicalensis georgi and human serum albumin", CHEMICAL JOURNAL OF CHINESE UNIVERSITIES, vol. 32, no. 2, 1 January 2011 (2011-01-01), pages 241 - 245, XP055526774
BI, SHUYUN ET AL.: "Investigation of the interaction between flavonoids and human serum albumin", JOURNAL OF MOLECULAR STRUCTURE, vol. 703, 31 December 2004 (2004-12-31), pages 37 - 45, XP055405482
BI, SHUYUN ET AL.: "Investigation of the interaction between flavonoids and human serum albumin", JOURNAL OF MOLECULAR STRUCTURE, vol. 703, 31 December 2004 (2004-12-31), pages 37 - 45, XP055405482
Attorney, Agent or Firm:
BEIJING JUNZHI INTELLECTUAL PROPERTY AGENCY (G. P.) (CN)
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