Title:
BASE-CATALYZED SYNTHESIS OF 1-ARYL-4-(ARYL ETHYL)PIPERAZINES FROM AROMATIC OLEFINS AND 1-ARYL PIPERAZINES
Document Type and Number:
WIPO Patent Application WO1999036412
Kind Code:
A3
Abstract:
The invention relates to a method for producing a 1-aryl-4-(aryl ethyl)piperazine of formula (I) by reacting a 1-aryl piperazine of formula (II) with an aromatic olefin of formula (III) Ar'CR<1>=CHR<2> in an inert solvent and in the presence of at least one basic catalyst, whereby in formulas (I) to (III); Ar and Ar', independent of one another, represent an aryl radical selected from the group of the condensed and non-condensed C6-C22-aromatic compounds and of the condensed or non-condensed C5-C22-heteroatoms which contain at least one nitrogen, oxygen or sulfur atom in the ring; R1 and R2, independent of one another, represent a hydrogen atom, a C1-C8-alkyl radical or an aryl radical Ar.
Inventors:
HERWIG JUERGEN (DE)
BELLER MATTHIAS (DE)
BREINDL CLAUDIA (DE)
BELLER MATTHIAS (DE)
BREINDL CLAUDIA (DE)
Application Number:
PCT/EP1998/008344
Publication Date:
September 16, 1999
Filing Date:
December 19, 1998
Export Citation:
Assignee:
HOECHST RES & TECH GMBH & CO (DE)
HERWIG JUERGEN (DE)
BELLER MATTHIAS (DE)
BREINDL CLAUDIA (DE)
HERWIG JUERGEN (DE)
BELLER MATTHIAS (DE)
BREINDL CLAUDIA (DE)
International Classes:
C07D295/02; C07B61/00; C07D295/023; C07D295/06; C07D295/073; C07D295/08; C07D295/096; (IPC1-7): C07D295/02; C07D295/06; C07D295/08
Foreign References:
| FR85503E | 1965-08-27 |
Other References:
BELLER M ET AL: "Base-Catalyzed Hydroamination of Aromatic Olefins-An Efficient Route to 1-Aryl-4-(arylethyl)piperazines", TETRAHEDRON, vol. 54, no. 23, 4 June 1998 (1998-06-04), pages 6359-6368, XP004119583, ISSN: 0040-4020
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